For Research Use Only. Not for use in diagnostic procedures.

Store all reagents at 2-8 degree C

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Small volumes of LTBP2 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS9373622 is a ready-to-use microwell, strip-or-full plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Latent Transforming Growth Factor Beta Binding Protein 2 (LTBP2) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing LTBP2. The ELISA analytical biochemical technique of the MBS9373622 kit is based on LTBP2 antibody-LTBP2 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect LTBP2 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, LTBP2. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

195,052 Da

latent transforming growth factor beta binding protein 2

latent-transforming growth factor beta-binding protein 2

Latent-transforming growth factor beta-binding protein 2

C14orf141; LTBP3; LTBP-2??[Similar Products]

LTBP2_HUMAN

The protein encoded by this gene belongs to the family of latent transforming growth factor (TGF)-beta binding proteins (LTBP), which are extracellular matrix proteins with multi-domain structure. This protein is the largest member of the LTBP family possessing unique regions and with most similarity to the fibrillins. It has thus been suggested that it may have multiple functions: as a member of the TGF-beta latent complex, as a structural component of microfibrils, and a role in cell adhesion. [provided by RefSeq, Jul 2008]

LTBP2: May play an integral structural role in elastic-fiber architectural organization and/or assembly. Defects in LTBP2 are the cause of primary congenital glaucoma type 3D (GLC3D). An autosomal recessive form of primary congenital glaucoma (PCG). PCG is characterized by marked increase of intraocular pressure at birth or early childhood, large ocular globes (buphthalmos) and corneal edema. It results from developmental defects of the trabecular meshwork and anterior chamber angle of the eye that prevent adequate drainage of aqueous humor. Defects in LTBP2 are the cause of microspherophakia (MCSPH). It is a rare disease characterized by smaller and more spherical lenses than normal bilaterally, an increased anteroposterior thickness of the lens and highly myopic eyes. Lens dislocation or subluxation may occur, leading to defective accommodation. Defects in LTBP2 are the cause of Weill-Marchesani syndrome 3 (WMS3). A rare connective tissue disorder characterized by short stature, brachydactyly, joint stiffness, and lens abnormalities. Belongs to the LTBP family.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 14q24

Cellular Component: extracellular matrix; extracellular space; proteinaceous extracellular matrix

Molecular Function: protein binding

Biological Process: fibril organization and biogenesis; protein secretion; protein targeting; transforming growth factor beta receptor signaling pathway

Disease: Glaucoma 3, Primary Congenital, D; Glaucoma 3, Primary Infantile, B; Microspherophakia And/or Megalocornea, With Ectopia Lentis And With Or Without Secondary Glaucoma; Weill-marchesani Syndrome 3

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