Ribosomal protein S6 kinase alpha-3; S6K-alpha-3; 90 kDa ribosomal protein S6 kinase 3; p90-RSK 3; p90RSK3; Insulin-stimulated protein kinase 1; ISPK-1; MAP kinase-activated protein kinase 1b; MAPK-activated protein kinase 1b; MAPKAP kinase 1b; MAPKAPK-1b; Ribosomal S6 kinase 2; RSK-2; pp90RSK2; RPS6KA3; ISPK1; MAPKAPK1B; RSK2

For Research Use Only. Not for use in diagnostic procedures.

Monoclonal

IgG1

356CT10.6.1.2

Mouse

Purified His-tagged RPS6KA3 protein(Fragment) was used to produced this monoclonal antibody.

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Vial Concentration: 2 (lot specific)

Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.

Small volumes of anti-RPS6KA3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

This gene encodes a member of the RSK (ribosomal S6
kinase) family of serine/threonine kinases. This kinase contains 2
non-identical kinase catalytic domains and phosphorylates various
substrates, including members of the mitogen-activated kinase
(MAPK) signalling pathway. The activity of this protein has been
implicated in controlling cell growth and differentiation.
Mutations in this gene have been associated with Coffin-Lowry
syndrome (CLS).

Signal Transduction

Western Blot (WB), ELISA (EIA)

WB~~1:100~500

RPS6KA3 Antibody western blot analysis in U251 cell line lysates (35ug/lane).This demonstrates the RPS6KA3 antibody detected the RPS6KA3 protein (arrow).

83736

ribosomal protein S6 kinase, 90kDa, polypeptide 3

ribosomal protein S6 kinase alpha-3

Ribosomal protein S6 kinase alpha-3

ISPK1; MAPKAPK1B; RSK2; S6K-alpha-3; p90-RSK 3; p90RSK3; ISPK-1; MAPK-activated protein kinase 1b; MAPKAP kinase 1b; MAPKAPK-1b; RSK-2??[Similar Products]

KS6A3_HUMAN

This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 non-identical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation. Mutations in this gene have been associated with Coffin-Lowry syndrome (CLS). [provided by RefSeq, Jul 2008]

RSK2: an AGC kinase of the RSK family. Phosphorylated and activated by Erk1 and -2 in response to many growth factors, polypeptide hormones and neurotransmitters. Several phosphorylation sites are important for its activation. Possesses two kinase domains connected by a regulator linker region. Phosphorylates a wide range of substrates including ribosomal protein S6. Prominently expressed in brain structures essential for cognitive function and learning.

Protein type: Protein kinase, AGC; EC 2.7.11.1; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); AGC group; RSK family; RSK subfamily

Chromosomal Location of Human Ortholog: Xp22.2-p22.1

Cellular Component: nucleoplasm; cytosol

Molecular Function: protein serine/threonine kinase activity; protein binding; caspase inhibitor activity; magnesium ion binding; protein kinase binding; ATP binding; protein kinase activity

Biological Process: axon guidance; central nervous system development; nerve growth factor receptor signaling pathway; stress-activated MAPK cascade; response to lipopolysaccharide; toll-like receptor 3 signaling pathway; negative regulation of caspase activity; signal transduction; protein amino acid phosphorylation; toll-like receptor 10 signaling pathway; toll-like receptor 5 signaling pathway; synaptic transmission; skeletal development; toll-like receptor 4 signaling pathway; regulation of transcription in response to stress; MyD88-independent toll-like receptor signaling pathway; regulation of translation in response to stress; cell cycle; positive regulation of cell growth; toll-like receptor 2 signaling pathway; MyD88-dependent toll-like receptor signaling pathway; toll-like receptor signaling pathway; innate immune response; positive regulation of transcription from RNA polymerase II promoter; toll-like receptor 9 signaling pathway; positive regulation of cell differentiation; negative regulation of apoptosis

Disease: Mental Retardation, X-linked 19; Coffin-lowry Syndrome

Peng, C., et al. FASEB J. 24(9):3490-3499(2010)
Vigneron, S., et al. Oncogene 29(24):3566-3574(2010)
Kang, S., et al. J. Clin. Invest. 120(4):1165-1177(2010)
Yerges, L.M., et al. J. Bone Miner. Res. 24(12):2039-2049(2009)
Doehn, U., et al. Mol. Cell 35(4):511-522(2009)

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