Product Name
RPS6KA3, Polyclonal Antibody
Full Product Name
RPS6KA3 Antibody - middle region
Product Gene Name
anti-RPS6KA3 antibody
[Similar Products]
Product Synonym Gene Name
CLS; RSK; HU-3; RSK2; MRX19; ISPK-1; p90-RSK2; pp90RSK2; MAPKAPK1B; S6K-alpha3[Similar Products]
Antibody/Peptide Pairs
RPS6KA3 peptide (MBS3245205) is used for blocking the activity of RPS6KA3 antibody (MBS3220404)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence
Synthetic peptide located within the following region: VLKRQGYDAA CDIWSLGVLL YTMLTGYTPF ANGPDDTPEE ILARIGSGKF
3D Structure
ModBase 3D Structure for P51812
Purity/Purification
Affinity purified
Form/Format
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Immunogen
The immunogen is a synthetic peptide directed towards the middle region of human RPS6KA3
Preparation and Storage
For short term use, store at 2-8 degree C up to 1 week. For long term storage, store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
Other Notes
Small volumes of anti-RPS6KA3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-RPS6KA3 antibody
This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 non-identical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation. Mutations in this gene have been associated with Coffin-Lowry syndrome (CLS).
Product Categories/Family for anti-RPS6KA3 antibody
Polyclonal;
Applications Tested/Suitable for anti-RPS6KA3 antibody
Western Blot (WB)
Western Blot (WB) of anti-RPS6KA3 antibody
Host: Rabbit
Target Name: RPS6KA3
Sample Tissue: Human HepG2 Whole Cell
Antibody Dilution: 1.0ug/ml
NCBI/Uniprot data below describe general gene information for RPS6KA3. It may not necessarily be applicable to this product.
NCBI Accession #
NP_004577.1
[Other Products]
NCBI GenBank Nucleotide #
NM_004586.2
[Other Products]
UniProt Primary Accession #
P51812
[Other Products]
UniProt Related Accession #
P51812[Other Products]
NCBI Official Full Name
ribosomal protein S6 kinase alpha-3
NCBI Official Synonym Full Names
ribosomal protein S6 kinase A3
NCBI Official Symbol
RPS6KA3??[Similar Products]
NCBI Official Synonym Symbols
CLS; RSK; HU-3; RSK2; MRX19; ISPK-1; p90-RSK2; pp90RSK2; MAPKAPK1B; S6K-alpha3
??[Similar Products]
NCBI Protein Information
ribosomal protein S6 kinase alpha-3
UniProt Protein Name
Ribosomal protein S6 kinase alpha-3
UniProt Synonym Protein Names
90 kDa ribosomal protein S6 kinase 3; p90-RSK 3; p90RSK3; Insulin-stimulated protein kinase 1; ISPK-1; MAP kinase-activated protein kinase 1b; MAPK-activated protein kinase 1b; MAPKAP kinase 1b; MAPKAPK-1b; Ribosomal S6 kinase 2; RSK-2; pp90RSK2
Protein Family
Ribosomal protein S6 kinase
UniProt Gene Name
RPS6KA3??[Similar Products]
UniProt Synonym Gene Names
ISPK1; MAPKAPK1B; RSK2; S6K-alpha-3; p90-RSK 3; p90RSK3; ISPK-1; MAPK-activated protein kinase 1b; MAPKAP kinase 1b; MAPKAPK-1b; RSK-2??[Similar Products]
UniProt Entry Name
KS6A3_HUMAN
NCBI Summary for RPS6KA3
This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 non-identical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation. Mutations in this gene have been associated with Coffin-Lowry syndrome (CLS). [provided by RefSeq, Jul 2008]
Research Articles on RPS6KA3
1. we showed that RPS6KA3 knockdown reduced the propagation of human AML cells in vivo in mice. Our results point to RSK2 as a novel Pim2 target with translational therapeutic potential in FLT3-ITD AML.
Precautions
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Disclaimer
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