Anti-RPS6KA3 / RSK2 Antibody (C-Terminus) IHC-plus; RPS6KA3; Coffin-Lowry syndrome; HU-2; ISPK1; MAPKAP kinase 1B; MAPKAPK-1b; MRX19; Ribosomal S6 kinase 2; RSK-2; p90-RSK 3; p90RSK3; RSK; RSK2; S6K-alpha-3; S6K-alpha3; CLS; ISPK-1; MAPKAPK1B; p90-RSK2; Pp90RSK2; Mouse RPS6KA3; RSK2

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

Rabbit

Specific for the ~90k RSK2 protein

Immunoaffinity Purified

10 mM HEPES (pH 7.5), 150 mM NaCl, 100 ug per ml BSA and 50% glycerol.

Long term: -20 degree C; Short term: +4 degree C; Avoid freeze-thaw cycles.

Small volumes of anti-RPS6KA3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

RSK2, an RSK serine/threonine kinase, has been implicated in Coffin-Lowry syndrome, a disease characterized by cognitive impairment, characteristic facial and digital findings and skeletal anomalies.

Subfamily:-RSK">Family: Protein Kinase
Subfamily: RSK

Immunohistochemistry (IHC - Paraffin), Western Blot (WB)

IHC-P (1:100), WB (1:1000)

Anti-RPS6KA3 / RSK2 antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:100.

Western blot of HeLa cell lysate showing specific immunolabeling of the ~90k RSK2 protein.

83,736 Da

ribosomal protein S6 kinase, 90kDa, polypeptide 3

ribosomal protein S6 kinase alpha-3; RSK-2; p90-RSK 3; MAPKAPK-1b; S6K-alpha-3; MAPKAP kinase 1b; ribosomal S6 kinase 2; MAPK-activated protein kinase 1b; insulin-stimulated protein kinase 1; MAP kinase-activated protein kinase 1b

Ribosomal protein S6 kinase alpha-3

ISPK1; MAPKAPK1B; RSK2; S6K-alpha-3; p90-RSK 3; p90RSK3; ISPK-1; MAPK-activated protein kinase 1b; MAPKAP kinase 1b; MAPKAPK-1b; RSK-2??[Similar Products]

KS6A3_HUMAN

This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 non-identical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation. Mutations in this gene have been associated with Coffin-Lowry syndrome (CLS). [provided by RefSeq, Jul 2008]

RSK2: an AGC kinase of the RSK family. Phosphorylated and activated by Erk1 and -2 in response to many growth factors, polypeptide hormones and neurotransmitters. Several phosphorylation sites are important for its activation. Possesses two kinase domains connected by a regulator linker region. Phosphorylates a wide range of substrates including ribosomal protein S6. Prominently expressed in brain structures essential for cognitive function and learning.

Protein type: Kinase, protein; EC 2.7.11.1; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); AGC group; RSK family; RSK subfamily

Chromosomal Location of Human Ortholog: Xp22.2-p22.1

Cellular Component: nucleoplasm; cytosol

Molecular Function: protein serine/threonine kinase activity; protein binding; caspase inhibitor activity; magnesium ion binding; protein kinase binding; ATP binding; protein kinase activity

Biological Process: axon guidance; central nervous system development; nerve growth factor receptor signaling pathway; stress-activated MAPK cascade; response to lipopolysaccharide; toll-like receptor 3 signaling pathway; negative regulation of caspase activity; signal transduction; protein amino acid phosphorylation; toll-like receptor 10 signaling pathway; toll-like receptor 5 signaling pathway; synaptic transmission; skeletal development; toll-like receptor 4 signaling pathway; regulation of transcription in response to stress; MyD88-independent toll-like receptor signaling pathway; regulation of translation in response to stress; cell cycle; positive regulation of cell growth; toll-like receptor 2 signaling pathway; MyD88-dependent toll-like receptor signaling pathway; toll-like receptor signaling pathway; innate immune response; positive regulation of transcription from RNA polymerase II promoter; toll-like receptor 9 signaling pathway; positive regulation of cell differentiation; negative regulation of apoptosis

Disease: Mental Retardation, X-linked 19; Coffin-lowry Syndrome

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