Full Product Name
Phospho-RSK2 (Tyr529) Antibody
Product Gene Name
anti-RSK2 antibody
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Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P51812
Species Reactivity
Human, Mouse
Concentration
1.0mg/ml (lot specific)
Other Notes
Small volumes of anti-RSK2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-RSK2 antibody
Western Blot (WB)
NCBI/Uniprot data below describe general gene information for RSK2. It may not necessarily be applicable to this product.
NCBI Accession #
NP_004577.1
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NCBI GenBank Nucleotide #
NM_004586.2
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UniProt Primary Accession #
P51812
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UniProt Secondary Accession #
Q4VAP3; Q59H26; Q5JPK8; Q7Z3Z7; B2R9V4[Other Products]
UniProt Related Accession #
P51812[Other Products]
Molecular Weight
83,736 Da
NCBI Official Full Name
ribosomal protein S6 kinase alpha-3
NCBI Official Synonym Full Names
ribosomal protein S6 kinase A3
NCBI Official Symbol
RPS6KA3??[Similar Products]
NCBI Official Synonym Symbols
CLS; RSK; HU-3; RSK2; MRX19; ISPK-1; p90-RSK2; pp90RSK2; MAPKAPK1B; S6K-alpha3
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NCBI Protein Information
ribosomal protein S6 kinase alpha-3
UniProt Protein Name
Ribosomal protein S6 kinase alpha-3
UniProt Synonym Protein Names
90 kDa ribosomal protein S6 kinase 3; p90-RSK 3; p90RSK3; Insulin-stimulated protein kinase 1; ISPK-1; MAP kinase-activated protein kinase 1b; MAPK-activated protein kinase 1b; MAPKAP kinase 1b; MAPKAPK-1b; Ribosomal S6 kinase 2; RSK-2; pp90RSK2
UniProt Gene Name
RPS6KA3??[Similar Products]
UniProt Synonym Gene Names
ISPK1; MAPKAPK1B; RSK2; S6K-alpha-3; p90-RSK 3; p90RSK3; ISPK-1; MAPK-activated protein kinase 1b; MAPKAP kinase 1b; MAPKAPK-1b; RSK-2??[Similar Products]
NCBI Summary for RSK2
This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 non-identical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation. Mutations in this gene have been associated with Coffin-Lowry syndrome (CLS). [provided by RefSeq, Jul 2008]
UniProt Comments for RSK2
RSK2: an AGC kinase of the RSK family. Phosphorylated and activated by Erk1 and -2 in response to many growth factors, polypeptide hormones and neurotransmitters. Several phosphorylation sites are important for its activation. Possesses two kinase domains connected by a regulator linker region. Phosphorylates a wide range of substrates including ribosomal protein S6. Prominently expressed in brain structures essential for cognitive function and learning.
Protein type: AGC group; EC 2.7.11.1; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); RSK family; RSK subfamily
Chromosomal Location of Human Ortholog: Xp22.12
Cellular Component: cytoplasm; cytosol; nucleoplasm; nucleus
Molecular Function: caspase inhibitor activity; kinase activity; protein binding; protein kinase activity; protein serine/threonine kinase activity
Biological Process: central nervous system development; negative regulation of apoptosis; negative regulation of caspase activity; positive regulation of cell differentiation; positive regulation of cell growth; positive regulation of transcription from RNA polymerase II promoter; regulation of transcription in response to stress; regulation of translation in response to stress; response to lipopolysaccharide; signal transduction; skeletal development; toll-like receptor signaling pathway
Disease: Coffin-lowry Syndrome; Mental Retardation, X-linked 19
Research Articles on RSK2
1. Data show that the 90 kDa ribosomal protein S6 kinases RSK1 and RSK2 play a key role in the homing of ovarian cancer cells in metastatic sites by regulating cell adhesion and invasion.
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