Product Name
SLC37A4, cDNA Clone
Full Product Name
SLC37A4 cDNA Clone
Product Gene Name
SLC37A4 cdna clone
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
atggcagccc agggctatgg ctattatcgc actgtgatct tctcagccat gtttgggggc tacagcctgt attacttcaa tcgcaagacc ttctcctttg tcatgccatc attggtggaa gagatccctt tggacaagga tgatttgggg ttcatcacca gcagccagtc ggcagcttat gctatcagca agtttgtcag tggggtgctg tctgaccaga tgagtgctcg ctggctcttc tcttctgggc tgctcctggt tggcctggtc aacatattct ttgcctggag ctccacagta cctgtctttg ctgccctctg gttccttaat ggcctggccc aggggctggg ctggccccca tgtgggaagg tcctgcggaa gtggtttgag ccatctcagt ttggcacttg gtgggccatc ctgtcaacca gcatgaacct ggctggaggg ctgggcccta tcctggcaac catccttgcc cagagctaca gctggcgcag cacgctggcc ctatctgggg cactgtgtgt ggttgtctcc ttcctctgtc tcctgctcat ccacaatgaa cctgctgatg ttggactccg caacctggac cccatgccct ctgagggcaa gaagggctcc ttgaaggagg agagcaccct gcaggagctg ctgctgtccc cttacctgtg ggtgctctcc actggttacc ttgtggtgtt tggagtaaag acctgctgta ctgactgggg ccagttcttc cttatccagg agaaaggaca gtcagccctt gtaggtagct cctacatgag tgccctggaa gttgggggcc ttgtaggcag catcgcagct ggctacctgt cagaccgggc catggcaaag gcgggactgt ccaactacgg gaaccctcgc catggcctgt tgctgttcat gatggctggc atgacagtgt ccatgtacct cttccgggta acagtgacca gtgactcccc caagctctgg atcctggtat tgggagctgt atttggtttc tcctcgtatg gccccattgc cctgtttgga gtcatagcca acgagagtgc ccctcccaac ttgtgtggca cctcccacgc cattgtggga ctcatggcca atgtgggcgg ctttctggct gggctgccct tcagcaccat tgccaagcac tacagttgga gcacagcctt ctgggtggct gaagtgattt gtgcggccag cacggctgcc ttcttcctcc tacgaaacat ccgcaccaag atgggccgag tgtccaagaa ggctgagtga
Clone Sequence Report
Provided with product shipment
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of SLC37A4 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for SLC37A4. It may not necessarily be applicable to this product.
NCBI Accession #
BC014663
[Other Products]
UniProt Secondary Accession #
O96016; Q5J7V4; Q9UI19; Q9UNS4[Other Products]
UniProt Related Accession #
O43826[Other Products]
Molecular Weight
48,840 Da
NCBI Official Full Name
Homo sapiens solute carrier family 37 (glucose-6-phosphate transporter), member 4, mRNA
NCBI Official Synonym Full Names
solute carrier family 37 member 4
NCBI Official Symbol
SLC37A4??[Similar Products]
NCBI Official Synonym Symbols
G6PT1; G6PT2; G6PT3; GSD1b; GSD1c; GSD1d; TRG19; TRG-19; PRO0685
??[Similar Products]
NCBI Protein Information
glucose-6-phosphate exchanger SLC37A4
UniProt Protein Name
Glucose-6-phosphate exchanger SLC37A4
UniProt Synonym Protein Names
Glucose-5-phosphate transporter; Glucose-6-phosphate translocase
Protein Family
Glucose-6-phosphate exchanger
UniProt Gene Name
SLC37A4??[Similar Products]
UniProt Synonym Gene Names
TRG-19??[Similar Products]
UniProt Entry Name
G6PT1_HUMAN
NCBI Summary for SLC37A4
This gene regulates glucose-6-phosphate transport from the cytoplasm to the lumen of the endoplasmic reticulum, in order to maintain glucose homeostasis. It also plays a role in ATP-mediated calcium sequestration in the lumen of the endoplasmic reticulum. Mutations in this gene have been associated with various forms of glycogen storage disease. Alternative splicing in this gene results in multiple transcript variants.[provided by RefSeq, Aug 2009]
UniProt Comments for SLC37A4
SLC37A4: Transports glucose-6-phosphate from the cytoplasm to the lumen of the endoplasmic reticulum. Forms with glucose-6- phosphatase the complex responsible for glucose production through glycogenolysis and gluconeogenesis. Hence, it plays a central role in homeostatic regulation of blood glucose levels. Defects in SLC37A4 are the cause of glycogen storage disease type 1B (GSD1B). GSD1B is a metabolic disorder characterized by impairment of terminal steps of glycogenolysis and gluconeogenesis. GSD1 patients manifest a wide range of clinical symptoms and biochemical abnormalities, including hypoglycemia, severe hepatomegaly due to excessive accumulation of glycogen, kidney enlargement, growth retardation, lactic acidemia, hyperlipidemia, and hyperuricemia. GSD1B patients also present a tendency towards infections associated with neutropenia, relapsing aphthous gingivostomatitis, and inflammatory bowel disease. Defects in SLC37A4 are the cause of glycogen storage disease type 1C (GSD1C). Defects in SLC37A4 are the cause of glycogen storage disease type 1D (GSD1D). Belongs to the major facilitator superfamily. Organophosphate:Pi antiporter (OPA) (TC 2.A.1.4) family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family
Chromosomal Location of Human Ortholog: 11q23.3
Cellular Component: endoplasmic reticulum membrane; integral to endoplasmic reticulum membrane; membrane
Molecular Function: glucose-6-phosphate transmembrane transporter activity
Biological Process: glucose transport; glucose-6-phosphate transport; positive regulation of defense response to virus by host
Disease: Glycogen Storage Disease Ib; Glycogen Storage Disease Ic
Research Articles on SLC37A4
1. Data suggest that G6PT modulates autophagy independent of its transport activity; G6PT appears to up-regulate autophagy via inactivation of mTORC1; knockdown of G6PT expression activates mTORC1 (mechanistic target of rapamycin complex 1) activity.
Precautions
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Disclaimer
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