Full Product Name
PITX3 Antibody
Product Gene Name
anti-PITX3 antibody
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Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for O75364
Other Notes
Small volumes of anti-PITX3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for PITX3. It may not necessarily be applicable to this product.
NCBI Accession #
NP_005020.1
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NCBI GenBank Nucleotide #
NM_005029.3
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UniProt Primary Accession #
O75364
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UniProt Secondary Accession #
Q5VZL2[Other Products]
UniProt Related Accession #
O75364[Other Products]
Molecular Weight
31,832 Da
NCBI Official Full Name
pituitary homeobox 3
NCBI Official Synonym Full Names
paired like homeodomain 3
NCBI Official Symbol
PITX3??[Similar Products]
NCBI Official Synonym Symbols
ASMD; ASOD; PTX3; ASGD1; CTPP4; CTRCT11
??[Similar Products]
NCBI Protein Information
pituitary homeobox 3
UniProt Protein Name
Pituitary homeobox 3
UniProt Synonym Protein Names
Homeobox protein PITX3; Paired-like homeodomain transcription factor 3
Protein Family
Pituitary homeobox
UniProt Gene Name
PITX3??[Similar Products]
UniProt Synonym Gene Names
PTX3??[Similar Products]
NCBI Summary for PITX3
This gene encodes a member of the RIEG/PITX homeobox family, which is in the bicoid class of homeodomain proteins. Members of this family act as transcription factors. This protein is involved in lens formation during eye development. Mutations of this gene have been associated with anterior segment mesenchymal dysgenesis and congenital cataracts. [provided by RefSeq, Jul 2008]
UniProt Comments for PITX3
Transcriptional regulator which is important for the differentiation and maintenance of meso-diencephalic dopaminergic (mdDA) neurons during development. In addition to its importance during development, it also has roles in the long-term survival and maintenance of the mdDA neurons. Activates NR4A2/NURR1-mediated transcription of genes such as SLC6A3, SLC18A2, TH and DRD2 which are essential for development of mdDA neurons. Acts by decreasing the interaction of NR4A2/NURR1 with the corepressor NCOR2/SMRT which acts through histone deacetylases (HDACs) to keep promoters of NR4A2/NURR1 target genes in a repressed deacetylated state. Essential for the normal lens development and differentiation. Plays a critical role in the maintenance of mitotic activity of lens epithelial cells, fiber cell differentiation and in the control of the temporal and spatial activation of fiber cell-specific crystallins. Positively regulates FOXE3 expression and negatively regulates PROX1 in the anterior lens epithelium, preventing activation of CDKN1B/P27Kip1 and CDKN1C/P57Kip2 and thus maintains lens epithelial cells in cell cycle ().
Research Articles on PITX3
1. Study showed that PITX3 methylation was significantly methylated in head and neck squamous cell carcinoma (HNSCC) tumor compared to normal adjacent tissue and correlated with lymph node status. These results provide evidence that PITX3 DNA methylation is an independent prognostic biomarker for overall survival in patients with HNSCC and might aid in the process of risk stratification for individualized treatment.
Precautions
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Disclaimer
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