Product Name
DNA repair protein complementing XP-A cells homolog (Xpa), Recombinant Protein
Full Product Name
Recombinant Mouse DNA repair protein complementing XP-A cells homolog (Xpa)
Product Gene Name
Xpa recombinant protein
[Similar Products]
Product Synonym Gene Name
Xpa[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Positions
2-272aa, Full Length of Mature Protein
Sequence
ATAEEKQTSP EPVAADEPAQ LPAAVRASVE RKRQRALMLR QARLAARPYP AAAATGGVAS VKAAPKMIDT KGGFILEEEE EKHEIGNIVH EPGPVMEFDY TICEECGKEF MDSYLMNHFD LPTCDSCRDA DDKHKLITKT EAKQEYLLKD CDLEKREPAL RFLVKKNPRH SQWGDMKLYL KLQVVKRALE VWGSQEALED AKEVRQENRE KMKQKKFDKK VKELRRAIRS SVWKRETTTH QHKYGPEENL EDDMYRKTCT LCGHELTYEK M
3D Structure
ModBase 3D Structure for Q64267
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
>85% (SDS-PAGE) (lot specific)
Form/Format
Liquid containing glycerol
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
Storage Buffer
Tris-based buffer, 50% glycerol
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of Xpa recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
Xpa recombinant protein
This gene encodes a zinc finger protein involved in DNA excision repair. The encoded protein is part of the NER (nucleotide excision repair) complext which is responsible for repair of UV radiation-induced photoproducts and DNA adducts induced by chemical carcinogens. Mutations in this gene are associated with xeroderma pigmentosum complementation group A. Alternatively spliced transcript variants have been found for this gene.
NCBI/Uniprot data below describe general gene information for Xpa. It may not necessarily be applicable to this product.
NCBI Accession #
NP_035858.2
[Other Products]
NCBI GenBank Nucleotide #
NM_011728.2
[Other Products]
UniProt Primary Accession #
Q64267
[Other Products]
UniProt Secondary Accession #
Q9CVA0; A2ALZ7[Other Products]
UniProt Related Accession #
Q64267[Other Products]
Molecular Weight
30,957 Da
NCBI Official Full Name
DNA repair protein complementing XP-A cells homolog
NCBI Official Synonym Full Names
xeroderma pigmentosum, complementation group A
NCBI Official Symbol
Xpa??[Similar Products]
NCBI Official Synonym Symbols
Xpac; AI573865
??[Similar Products]
NCBI Protein Information
DNA repair protein complementing XP-A cells homolog
UniProt Protein Name
DNA repair protein complementing XP-A cells homolog
UniProt Synonym Protein Names
Xeroderma pigmentosum group A-complementing protein homolog
Protein Family
DNA repair protein
UniProt Gene Name
Xpa??[Similar Products]
UniProt Synonym Gene Names
Xpac??[Similar Products]
UniProt Comments for Xpa
Involved in DNA excision repair. Initiates repair by binding to damaged sites with various affinities, depending on the photoproduct and the transcriptional state of the region. Required for UV-induced CHEK1 phosphorylation and the recruitment of CEP164 to cyclobutane pyrimidine dimmers (CPD), sites of DNA damage after UV irradiation ().
Research Articles on Xpa
1. The authors' results suggest that lack of the DNA repair factor XPA may delay neurobehavioral recovery after TBI
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
