Bovine TFIIH basal transcription factor complex helicase XPD subunit (ERCC2) ELISA kit; COFS2; EM9; MGC102762; MGC126218; MGC126219; TTD; XPD; excision repair cross-complementing rodent repair deficiency; complementation group 2 protein; xeroderma pigmentosum complementary group D; excision repair cross-complementing rodent repair deficiency; complementation group 2

For Research Use Only. Not for use in diagnostic procedures.

Store all reagents at 2-8 degree C

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Small volumes of ERCC2 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS9332153 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the excision repair cross-complementing rodent repair deficiency, complementation group 2 (ERCC2) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing ERCC2. The ELISA analytical biochemical technique of the MBS9332153 kit is based on ERCC2 antibody-ERCC2 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect ERCC2 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, ERCC2. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

86,999 Da

TFIIH basal transcription factor complex helicase XPD subunit; CXPD; DNA excision repair protein ERCC-2; DNA repair protein complementing XP-D cells; xeroderma pigmentosum group D-complementing protein; TFIIH basal transcription factor complex helicase subunit; excision repair cross-complementing rodent repair deficiency, complementation group 6-like group 2; excision repair cross-complementing rodent repair deficiency, complementation group 2 (xeroderma pigmentosum D)

TFIIH basal transcription factor complex helicase XPD subunit

ERCC2_BOVIN

Function: ATP-dependent 5'-3' DNA helicase, component of the core-TFIIH basal transcription factor. Involved in nucleotide excision repair (NER) of DNA by opening DNA around the damage, and in RNA transcription by RNA polymerase II by anchoring the CDK-activating kinase (CAK) complex, composed of CDK7, cyclin H and MAT1, to the core-TFIIH complex. Involved in the regulation of vitamin-D receptor activity. As part of the mitotic spindle-associated MMXD complex it plays a role in chromosome segregation. Might have a role in aging process and could play a causative role in the generation of skin cancers

Catalytic activity: ATP + H2O = ADP + phosphate.

Cofactor: Magnesium

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