Mouse DNA repair endonuclease XPF (ERCC4) ELISA kit; ERCC11; RAD1; XPF; DNA excision repair protein ERCC-4; DNA repair endonuclease XPF; excision-repair; complementing defective; in Chinese hamster; xeroderma pigmentosum; complementation group F; excision repair cross-complementing rodent repair deficiency; complementation group 4

For Research Use Only. Not for use in diagnostic procedures.

Store all reagents at 2-8 degree C

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Small volumes of ERCC4 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS9332527 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the excision repair cross-complementing rodent repair deficiency, complementation group 4 (ERCC4) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing ERCC4. The ELISA analytical biochemical technique of the MBS9332527 kit is based on ERCC4 antibody-ERCC4 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect ERCC4 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, ERCC4. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

103,690 Da

excision repair cross-complementing rodent repair deficiency, complementation group 4

DNA repair endonuclease XPF; DNA repair endonuclease subunit; DNA excision repair protein ERCC-4

DNA repair endonuclease XPF

XPF_MOUSE

ERCC4: Structure-specific DNA repair endonuclease responsible for the 5-prime incision during DNA repair. Involved in homologous recombination that assists in removing interstrand cross-link. Defects in ERCC4 are the cause of xeroderma pigmentosum complementation group F (XP-F); also known as xeroderma pigmentosum VI (XP6). XP-F is an autosomal recessive disease characterized by hypersensitivity of the skin to sunlight followed by high incidence of skin cancer and frequent neurologic abnormalities. Defects in ERCC4 are a cause of XFE progeroid syndrome (XFEPS). This syndrome is illustrated by one patient who presented with dwarfism, cachexia and microcephaly. Belongs to the XPF family.

Protein type: Deoxyribonuclease; DNA repair, damage; EC 3.1.-.-

Cellular Component: nucleotide-excision repair complex; chromosome, telomeric region; transcription factor TFIID complex; nuclear chromosome, telomeric region; nucleus

Molecular Function: protein C-terminus binding; nuclease activity; structure-specific DNA binding; hydrolase activity; single-stranded DNA specific endodeoxyribonuclease activity; protein N-terminus binding; T/G mismatch-specific endonuclease activity; endodeoxyribonuclease activity; phosphoric ester hydrolase activity; protein binding; nucleic acid binding; DNA binding; endonuclease activity; damaged DNA binding; single-stranded DNA binding

Biological Process: nucleotide-excision repair, DNA incision; DNA repair; DNA catabolic process, endonucleolytic; double-strand break repair via homologous recombination; nucleotide-excision repair, DNA incision, 3'-to lesion; negative regulation of telomere maintenance; UV protection; nucleotide-excision repair; resolution of meiotic joint molecules as recombinants; nucleotide-excision repair, DNA incision, 5'-to lesion; response to DNA damage stimulus; DNA metabolic process; telomere maintenance; response to UV

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