Human DNA repair endonuclease XPF (ERCC4) ELISA kit; ERCC11; RAD1; XPF; DNA excision repair protein ERCC-4; DNA repair endonuclease XPF; excision-repair; complementing defective; in Chinese hamster; xeroderma pigmentosum; complementation group F; excision repair cross-complementing rodent repair deficiency; complementation group 4

For Research Use Only. Not for use in diagnostic procedures.

No significant cross-reactivity or interference between this analyte and analogues is observed.

Store all reagents at 2-8 degree C

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Small volumes of ERCC4 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS9328610 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the excision repair cross-complementing rodent repair deficiency, complementation group 4 (ERCC4) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing ERCC4. The ELISA analytical biochemical technique of the MBS9328610 kit is based on ERCC4 antibody-ERCC4 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect ERCC4 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, ERCC4. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

Background: This Quantitative Sandwich ELISA kit is only for in vitro research use only, not for drug, household, therapeutic or diagnostic applications! This kit is intended to be used for determination the level of ERCC4 (hereafter termed "analyte") in undiluted original Human body fluids, tissue homogenates, secretions or feces samples. This kit is NOT suitable for assaying non-biological sources of substances.

104,486 Da

excision repair cross-complementation group 4

DNA repair endonuclease XPF; DNA excision repair protein ERCC-4; DNA repair protein complementing XP-F cells; xeroderma pigmentosum, complementation group F; xeroderma pigmentosum group F-complementing protein; excision-repair, complementing defective, in Chinese hamster; excision repair cross-complementing rodent repair deficiency, complementation group 4

DNA repair endonuclease XPF

ERCC11; XPF??[Similar Products]

XPF_HUMAN

The protein encoded by this gene forms a complex with ERCC1 and is involved in the 5' incision made during nucleotide excision repair. This complex is a structure specific DNA repair endonuclease that interacts with EME1. Defects in this gene are a cause of xeroderma pigmentosum complementation group F (XP-F), or xeroderma pigmentosum VI (XP6).[provided by RefSeq, Mar 2009]

ERCC4: Structure-specific DNA repair endonuclease responsible for the 5-prime incision during DNA repair. Involved in homologous recombination that assists in removing interstrand cross-link. Defects in ERCC4 are the cause of xeroderma pigmentosum complementation group F (XP-F); also known as xeroderma pigmentosum VI (XP6). XP-F is an autosomal recessive disease characterized by hypersensitivity of the skin to sunlight followed by high incidence of skin cancer and frequent neurologic abnormalities. Defects in ERCC4 are a cause of XFE progeroid syndrome (XFEPS). This syndrome is illustrated by one patient who presented with dwarfism, cachexia and microcephaly. Belongs to the XPF family.

Protein type: EC 3.1.-.-; Deoxyribonuclease; DNA repair, damage

Chromosomal Location of Human Ortholog: 16p13.12

Cellular Component: nucleoplasm; nucleotide-excision repair complex; chromosome, telomeric region; transcription factor TFIID complex; nuclear chromosome, telomeric region; nucleus

Molecular Function: protein C-terminus binding; protein binding; structure-specific DNA binding; single-stranded DNA specific endodeoxyribonuclease activity; damaged DNA binding; protein N-terminus binding; single-stranded DNA binding; endodeoxyribonuclease activity

Biological Process: nucleotide-excision repair, DNA incision; DNA repair; DNA catabolic process, endonucleolytic; double-strand break repair via homologous recombination; nucleotide-excision repair, DNA incision, 3'-to lesion; negative regulation of telomere maintenance; UV protection; nucleotide-excision repair; transcription-coupled nucleotide-excision repair; resolution of meiotic joint molecules as recombinants; nucleotide-excision repair, DNA damage removal; telomere maintenance; nucleotide-excision repair, DNA incision, 5'-to lesion; response to UV

Disease: Fanconi Anemia, Complementation Group Q; Xeroderma Pigmentosum, Complementation Group F; Xfe Progeroid Syndrome; Tracheoesophageal Fistula With Or Without Esophageal Atresia

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