Mouse Endonuclease 8-like 1 (NEIL1) ELISA kit; FLJ22402; FPG1; NEI1; hFPG1; endonuclease VIII; nei endonuclease VIII-like 1; nei endonuclease VIII-like 1 (E. coli)

For Research Use Only. Not for use in diagnostic procedures.

Store all reagents at 2-8 degree C

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Small volumes of NEIL1 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS9319684 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the nei endonuclease VIII-like 1 (E. coli) (NEIL1) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing NEIL1. The ELISA analytical biochemical technique of the MBS9319684 kit is based on NEIL1 antibody-NEIL1 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect NEIL1 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, NEIL1. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

43,586 Da

nei endonuclease VIII-like 1 (E. coli)

endonuclease 8-like 1; NEH1; nei homolog 1; endonuclease VIII; nei-like protein 1; endonuclease VIII-like 1; DNA glycosylase/AP lyase Neil1; DNA-(apurinic or apyrimidinic site) lyase Neil1

Endonuclease 8-like 1

Nei1; NEH1??[Similar Products]

NEIL1_MOUSE

NEIL1: Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, formamidopyrimidine (Fapy) and 5-hydroxyuracil. Has marginal activity towards 8- oxoguanine. Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. Has DNA glycosylase/lyase activity towards mismatched uracil and thymine, in particular in U:C and T:C mismatches. Belongs to the FPG family.

Protein type: Lyase; EC 4.2.99.18; DNA repair, damage; Hydrolase

Cellular Component: nucleoplasm; cytoskeleton; cytoplasm; chromosome; nucleus

Molecular Function: single-strand selective uracil DNA N-glycosylase activity; protein C-terminus binding; hydrolase activity, hydrolyzing N-glycosyl compounds; uracil DNA N-glycosylase activity; DNA-(apurinic or apyrimidinic site) lyase activity; zinc ion binding; hydrolase activity; DNA N-glycosylase activity; hydrolase activity, acting on glycosyl bonds; lyase activity; purine-specific mismatch base pair DNA N-glycosylase activity; DNA-3-methyladenine glycosylase III activity; nucleic acid binding; DNA binding; damaged DNA binding; catalytic activity

Biological Process: base-excision repair; nucleotide-excision repair; metabolic process; response to oxidative stress; DNA repair; response to DNA damage stimulus; negative regulation of nuclease activity

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