Human B-cell lymphoma/leukemia 10 (BCL10) ELISA kit; CARMEN; CIPER; CLAP; c-E10; mE10; CARD containing molecule enhancing NF-kB; CARD-containing apoptotic signaling protein; CARD-containing proapoptotic protein; OTTHUMP00000011647; OTTHUMP00000036080; casp; B-cell CLL/lymphoma 10

For Research Use Only. Not for use in diagnostic procedures.

Store all reagents at 2-8 degree C

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Small volumes of BCL10 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS9332274 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the B-cell CLL/lymphoma 10 (BCL10) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing BCL10. The ELISA analytical biochemical technique of the MBS9332274 kit is based on BCL10 antibody-BCL10 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect BCL10 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, BCL10. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

26,252 Da

B-cell CLL/lymphoma 10

B-cell lymphoma/leukemia 10; hCLAP; cCARMEN; cellular-E10; cellular homolog of vCARMEN; CARD-containing proapoptotic protein; CARD containing molecule enhancing NF-kB; CARD-containing apoptotic signaling protein; caspase-recruiting domain-containing protein; CARD-containing molecule enhancing NF-kappa-B; mammalian CARD-containing adapter molecule E10; CED-3/ICH-1 prodomain homologous E10-like regulator

B-cell lymphoma/leukemia 10

CIPER; CLAP; Bcl-10; hCLAP; CIPER; cCARMEN; c-E10; mE10??[Similar Products]

BCL10_HUMAN

This gene was identified by its translocation in a case of mucosa-associated lymphoid tissue (MALT) lymphoma. The protein encoded by this gene contains a caspase recruitment domain (CARD), and has been shown to induce apoptosis and to activate NF-kappaB. This protein is reported to interact with other CARD domain containing proteins including CARD9, 10, 11 and 14, which are thought to function as upstream regulators in NF-kappaB signaling. This protein is found to form a complex with MALT1, a protein encoded by another gene known to be translocated in MALT lymphoma. MALT1 and this protein are thought to synergize in the activation of NF-kappaB, and the deregulation of either of them may contribute to the same pathogenetic process that leads to the malignancy. [provided by RefSeq, Jul 2008]

Bcl-10: a ubiquitous pro-apoptotic protein that promotes pro-caspase-9 maturation and activation of NF-kappa-B via NIK and IKK. May be an adapter protein between upstream TNFR1-TRADD-RIP complex and the downstream NIK-IKK-IKAP complex. Self-associates via CARD-CARD interactions; forms a tight complex with MALT1. Interacts with other CARD-proteins such as CARD9, CARD10, CARD11 and CARD14. Binds caspase-9 with its C-terminal domain. Interacts with TRAF2 and BIRC2/c-IAP2. Defects in BCL10 are involved in various types of cancer.

Protein type: Tumor suppressor; Apoptosis; Transcription, coactivator/corepressor

Chromosomal Location of Human Ortholog: 1p22

Cellular Component: CBM complex; T cell receptor complex; protein complex; cytoplasmic microtubule; lysosome; perinuclear region of cytoplasm; cytoplasm; plasma membrane; immunological synapse; lipopolysaccharide receptor complex; nucleus; cytosol; lipid raft

Molecular Function: protein C-terminus binding; protein kinase B binding; ubiquitin binding; protease binding; protein self-association; transcription coactivator activity; transcription factor binding; protein kinase binding; NF-kappaB binding; protein binding; enzyme binding; ubiquitin protein ligase binding; kinase activator activity; kinase binding

Biological Process: cell death; response to fungus; positive regulation of transcription, DNA-dependent; B cell apoptosis; positive regulation of caspase activity; T cell receptor signaling pathway; interleukin-6 biosynthetic process; activation of NF-kappaB transcription factor; negative regulation of mature B cell apoptosis; response to molecule of bacterial origin; protein homooligomerization; response to food; adaptive immune response; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of interleukin-8 biosynthetic process; protein oligomerization; positive regulation of protein ubiquitination; regulation of T cell receptor signaling pathway; lymphotoxin A biosynthetic process; neural tube closure; toll-like receptor signaling pathway; innate immune response; cellular defense response; immunoglobulin mediated immune response; positive regulation of mast cell cytokine production; positive regulation of T cell activation; positive regulation of phosphorylation

Disease: Follicular Lymphoma, Susceptibility To, 1; Mesothelioma, Malignant; Testicular Germ Cell Tumor; Gastric Lymphoma, Primary; Immunodeficiency 37

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