DNA-repair protein complementing XP-A cells; XPAC; Xeroderma pigmentosum group A complementing protein

For Research Use Only. Not for use in diagnostic procedures.

XPA antibody detects endogenous levels of total XPA protein.

Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

In phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Store at-20 degree C for 1 year.

Small volumes of anti-XPA antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Autophagy antibody; Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells

Western Blot (WB), Immunohistochemistry (IHC), ELISA (EIA)

WB: 1:500~1:1000
IHC: 1:50~1:100
ELISA: 1:5000

Peptide-+

Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue using XPA antibody. Western blot analysis of extracts from COLO205 cells, using XPA antibody.

31,368 Da

XPA, DNA damage recognition and repair factor

DNA repair protein complementing XP-A cells

DNA repair protein complementing XP-A cells

XPAC??[Similar Products]

This gene encodes a zinc finger protein plays a central role in nucleotide excision repair (NER), a specialized type of DNA repair. NER is responsible for repair of UV radiation-induced photoproducts and DNA adducts induced by chemical carcinogens and chemotherapeutic drugs. The encoded protein interacts with DNA and several NER proteins, acting as a scaffold to assemble the NER incision complex at sites of DNA damage. Mutations in this gene cause Xeroderma pigmentosum complementation group A (XP-A), an autosomal recessive skin disorder featuring hypersensitivity to sunlight and increased risk for skin cancer. [provided by RefSeq, Aug 2017]

Involved in DNA excision repair. Initiates repair by binding to damaged sites with various affinities, depending on the photoproduct and the transcriptional state of the region. Required for UV-induced CHEK1 phosphorylation and the recruitment of CEP164 to cyclobutane pyrimidine dimmers (CPD), sites of DNA damage after UV irradiation.

Gary W. Daughdrill, Nucleic Acids Res., Jul 2003; 31: 4176-4183. Esther M. Hoogervorst, Carcinogenesis, Mar 2003; 24: 613-619. Karen M. Vasquez, PNAS, Apr 2002; 99: 5848.

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