Full Product Name
XPA Antibody
Product Synonym Names
DNA repair protein complementing XP-A cells; Xeroderma pigmentosum group A-complementing protein; XPA; XPAC
Product Gene Name
anti-XPA antibody
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Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P23025
Species Reactivity
Human, Mouse
Specificity
XPA Antibody detects endogenous levels of total XPA protein.
Purity/Purification
Purified from rabbit antiserum by affinity-chromatography using immunogen.
Form/Format
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration
1 mg/ml (lot specific)
Target Modification
Unmodified/Total
Immunogen
The antiserum was produced against synthesized peptide derived from human XPA.
Preparation and Storage
Stable at -20 degree C for at least 1 year.
Other Notes
Small volumes of anti-XPA antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-XPA antibody
Western Blot (WB), Immunohistochemistry (IHC), ELISA (EIA)
Application Notes for anti-XPA antibody
WB: 1:500~1:1000
IHC: 1:50~1:100
ELISA: 1:5000
Immunohistochemistry (IHC) of anti-XPA antibody
Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue, using XPA Antibody. The picture on the right is blocked with the synthesized peptide.
Western Blot (WB) of anti-XPA antibody
Western blot analysis of lysates from COLO205 cells, using XPA Antibody. The lane on the right is blocked with the synthesized peptide.
NCBI/Uniprot data below describe general gene information for XPA. It may not necessarily be applicable to this product.
NCBI Accession #
NP_000371.1
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NCBI GenBank Nucleotide #
NM_000380.3
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UniProt Primary Accession #
P23025
[Other Products]
UniProt Secondary Accession #
Q5T1U9; Q6LCW7; Q6LD02[Other Products]
UniProt Related Accession #
P23025[Other Products]
NCBI Official Full Name
DNA repair protein complementing XP-A cells isoform 1
NCBI Official Synonym Full Names
XPA, DNA damage recognition and repair factor
NCBI Official Symbol
XPA??[Similar Products]
NCBI Official Synonym Symbols
XP1; XPAC
??[Similar Products]
NCBI Protein Information
DNA repair protein complementing XP-A cells
UniProt Protein Name
DNA repair protein complementing XP-A cells
UniProt Synonym Protein Names
Xeroderma pigmentosum group A-complementing protein
Protein Family
DNA repair protein
UniProt Gene Name
XPA??[Similar Products]
UniProt Synonym Gene Names
XPAC??[Similar Products]
NCBI Summary for XPA
This gene encodes a zinc finger protein plays a central role in nucleotide excision repair (NER), a specialized type of DNA repair. NER is responsible for repair of UV radiation-induced photoproducts and DNA adducts induced by chemical carcinogens and chemotherapeutic drugs. The encoded protein interacts with DNA and several NER proteins, acting as a scaffold to assemble the NER incision complex at sites of DNA damage. Mutations in this gene cause Xeroderma pigmentosum complementation group A (XP-A), an autosomal recessive skin disorder featuring hypersensitivity to sunlight and increased risk for skin cancer. [provided by RefSeq, Aug 2017]
UniProt Comments for XPA
Involved in DNA excision repair. Initiates repair by binding to damaged sites with various affinities, depending on the photoproduct and the transcriptional state of the region. Required for UV-induced CHEK1 phosphorylation and the recruitment of CEP164 to cyclobutane pyrimidine dimmers (CPD), sites of DNA damage after UV irradiation.
Research Articles on XPA
1. XPA status does not globally influence human gene transcription. However, XPA significantly influences expression of a small subset of genes important for mitochondrial functions and steroid hormone metabolism.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
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