Product Name
Heat Shock Transcription Factor 4 (HSF4), Polyclonal Antibody
Full Product Name
Biotin-Linked Polyclonal Antibody to Heat Shock Transcription Factor 4 (HSF4)
Product Synonym Names
CTM; Heat Shock Factor Protein 4; Cataract,Marner
Product Gene Name
anti-HSF4 antibody
[Similar Products]
Matching Pairs
Unconjugated Antibody: Heat Shock Transcription Factor 4 (MBS2026933)
Biotin Conjugated Antibody: Heat Shock Transcription Factor 4 (HSF4) (MBS2092705)
Matching Pairs
Biotin Conjugated Antibody: Heat Shock Transcription Factor 4 (HSF4) (MBS2092705)
Immunogen: Heat Shock Transcription Factor 4 (MBS2029494)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q9ULV5
Concentration
200ug/ml (lot specific)
Immunogen
HSF4 (Leu91~Met407)
ISO Certification
Manufactured in an ISO 9001:2008 and ISO 13485:2003 Certified Laboratory.
Supply Chain Verification
Manufactured in a lab with traceable raw materials. Bulk orders can typically be prepared to the customera??s specifications, please inquire.
Other Notes
Small volumes of anti-HSF4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-HSF4 antibody
Western Blot (WB), Immunohistochemistry (IHC)
NCBI/Uniprot data below describe general gene information for HSF4. It may not necessarily be applicable to this product.
NCBI Accession #
Q9ULV5.2
[Other Products]
UniProt Primary Accession #
Q9ULV5
[Other Products]
UniProt Secondary Accession #
Q99472; Q9ULV6[Other Products]
UniProt Related Accession #
Q9ULV5[Other Products]
Molecular Weight
49,952 Da
NCBI Official Full Name
Heat shock factor protein 4
NCBI Official Synonym Full Names
heat shock transcription factor 4
NCBI Official Symbol
HSF4??[Similar Products]
NCBI Official Synonym Symbols
CTM; CTRCT5
??[Similar Products]
NCBI Protein Information
heat shock factor protein 4
UniProt Protein Name
Heat shock factor protein 4
UniProt Synonym Protein Names
Heat shock transcription factor 4; HSTF 4
Protein Family
Heat shock factor protein
UniProt Gene Name
HSF4??[Similar Products]
UniProt Synonym Gene Names
HSF 4; hHSF4; HSTF 4??[Similar Products]
NCBI Summary for HSF4
Heat-shock transcription factors (HSFs) activate heat-shock response genes under conditions of heat or other stresses. HSF4 lacks the carboxyl-terminal hydrophobic repeat which is shared among all vertebrate HSFs and has been suggested to be involved in the negative regulation of DNA binding activity. Two alternatively spliced transcripts encoding distinct isoforms and possessing different transcriptional activity have been described. [provided by RefSeq, Jul 2008]
UniProt Comments for HSF4
HSF4: DNA-binding protein that specifically binds heat shock promoter elements (HSE). Isoform HSF4A represses transcription while the isoform HSF4B activates transcription. Defects in HSF4 are the cause of cataract, zonular (CZ). A form of zonular cataract. Zonular or lamellar cataracts are opacities, broad or narrow, usually consisting of powdery white dots affecting only certain layers or zones between the cortex and nucleus of an otherwise clear lens. The opacity may be so dense as to render the entire central region of the lens completely opaque, or so translucent that vision is hardly if at all impeded. Zonular cataracts generally do not involve the embryonic nucleus, though sometimes they involve the fetal nucleus. Usually sharply separated from a clear cortex outside them, they may have projections from their outer edges known as riders or spokes. Defects in HSF4 are the cause of cataract Marner type (CAM). A form of cataract with variable and progressive opacities. Affected individuals present with zonular cataract, although some have nuclear, anterior polar, or stellate cataract. Finger malformation is observed in some kindreds. Belongs to the HSF family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Cell development/differentiation; DNA-binding; Transcription, coactivator/corepressor
Chromosomal Location of Human Ortholog: 16q22.1
Cellular Component: nuclear speck
Molecular Function: DNA binding transcription factor activity; sequence-specific DNA binding; transcription corepressor activity
Biological Process: camera-type eye development; cell development; histone H3-K9 demethylation; negative regulation of transcription from RNA polymerase II promoter; positive regulation of cell differentiation; positive regulation of cell proliferation; positive regulation of transcription from RNA polymerase II promoter; regulation of transcription, DNA-templated; transcription, DNA-dependent; visual perception
Disease: Cataract 5, Multiple Types
Research Articles on HSF4
1. C, p.Leu174Pro) in two sibs with congenital cataracts">report on a novel homozygous HSF4 mutation (c.521T>C, p.Leu174Pro) in two sibs with congenital cataracts
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