Full Product Name
HSF4 Antibody
Product Synonym Names
CTM
Product Gene Name
anti-HSF4 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Species Reactivity
Human, Mouse, Rat
Purity/Purification
Antigen affinity purification
Immunogen
Fusion protein of HSF4
Calculated Molecular Weight: 492aa; 53kd
Observed Molecular Weight: 62-66 kDa
Buffer
PBS with 0.0.2% sodium azide and 50% glycerol pH 7.3.
Santa Cruz Alternative
Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-19860 / sc-19863 / sc-19859 / sc-23720 / sc-19864
Preparation and Storage
Store at -20 degree C. Avoid freeze / thaw cycles
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Other Notes
Small volumes of anti-HSF4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-HSF4 antibody
ELISA (EIA), Western Blot (WB)
Application Notes for anti-HSF4 antibody
WB: 1:500-1:5000
Testing Data of anti-HSF4 antibody
NCBI/Uniprot data below describe general gene information for HSF4. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001529.2
[Other Products]
NCBI GenBank Nucleotide #
NM_001538.3
[Other Products]
UniProt Secondary Accession #
Q99472; Q9ULV6[Other Products]
UniProt Related Accession #
Q9ULV5[Other Products]
Molecular Weight
49,952 Da
NCBI Official Full Name
heat shock factor protein 4 isoform a
NCBI Official Synonym Full Names
heat shock transcription factor 4
NCBI Official Symbol
HSF4??[Similar Products]
NCBI Official Synonym Symbols
CTM; CTRCT5
??[Similar Products]
NCBI Protein Information
heat shock factor protein 4; HSF 4; HSTF 4; hHSF4
UniProt Protein Name
Heat shock factor protein 4
UniProt Synonym Protein Names
Heat shock transcription factor 4; HSTF 4
Protein Family
Heat shock factor protein
UniProt Gene Name
HSF4??[Similar Products]
UniProt Synonym Gene Names
HSF 4; hHSF4; HSTF 4??[Similar Products]
UniProt Entry Name
HSF4_HUMAN
NCBI Summary for HSF4
Heat-shock transcription factors (HSFs) activate heat-shock response genes under conditions of heat or other stresses. HSF4 lacks the carboxyl-terminal hydrophobic repeat which is shared among all vertebrate HSFs and has been suggested to be involved in the negative regulation of DNA binding activity. Two alternatively spliced transcripts encoding distinct isoforms and possessing different transcriptional activity have been described. [provided by RefSeq, Jul 2008]
UniProt Comments for HSF4
HSF4: DNA-binding protein that specifically binds heat shock promoter elements (HSE). Isoform HSF4A represses transcription while the isoform HSF4B activates transcription. Defects in HSF4 are the cause of cataract, zonular (CZ). A form of zonular cataract. Zonular or lamellar cataracts are opacities, broad or narrow, usually consisting of powdery white dots affecting only certain layers or zones between the cortex and nucleus of an otherwise clear lens. The opacity may be so dense as to render the entire central region of the lens completely opaque, or so translucent that vision is hardly if at all impeded. Zonular cataracts generally do not involve the embryonic nucleus, though sometimes they involve the fetal nucleus. Usually sharply separated from a clear cortex outside them, they may have projections from their outer edges known as riders or spokes. Defects in HSF4 are the cause of cataract Marner type (CAM). A form of cataract with variable and progressive opacities. Affected individuals present with zonular cataract, although some have nuclear, anterior polar, or stellate cataract. Finger malformation is observed in some kindreds. Belongs to the HSF family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: DNA-binding; Cell development/differentiation; Transcription, coactivator/corepressor
Chromosomal Location of Human Ortholog: 16q21
Cellular Component: nucleoplasm
Molecular Function: sequence-specific DNA binding; transcription corepressor activity; transcription factor activity; protein phosphatase binding
Biological Process: camera-type eye development; histone H3-K9 demethylation; transcription, DNA-dependent; regulation of transcription, DNA-dependent; positive regulation of cell proliferation; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription from RNA polymerase II promoter; positive regulation of cell differentiation; cell development
Disease: Cataract 5, Multiple Types
Research Articles on HSF4
1. T (p. K23N), in exon 3 of the HSF4 locus on 16q21-q22 associated with bilateral congenital cataracts in a Chinese family.">This is the first report of the novel missense mutation, c.69 G-->T (p. K23N), in exon 3 of the HSF4 locus on 16q21-q22 associated with bilateral congenital cataracts in a Chinese family.
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