Rat Espin (ESPN) ELISA kit; LP2654; DFNB36; DKFZp434A196; DKFZp434G2126; ectoplasmic specialization protein; espin

For Research Use Only. Not for use in diagnostic procedures.

Store all reagents at 2-8 degree C

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Small volumes of ESPN elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS9336729 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the espin (ESPN) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing ESPN. The ELISA analytical biochemical technique of the MBS9336729 kit is based on ESPN antibody-ESPN antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect ESPN antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, ESPN. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

90,569 Da

espin

espin; Jerker, deafness locus; ectoplasmic specialization protein; actin cytoskeletal regulatory protein

Espin

ESPN_RAT

is a fusion protein which binds actin filaments to each other and to the membranes [RGD, Feb 2006]

ESPN: Multifunctional actin-bundling protein. Plays a major role in regulating the organization, dimensions, dynamics and signaling capacities of the actin filament-rich, microvillus-type specializations that mediate sensory transduction in variouS mechanosensory and chemosensory cells. Defects in ESPN are the cause of deafness autosomal recessive type 36 with or without vestibular involvement (DFNB36). A form of non-syndromic sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Actin-binding; Cytoskeletal

Cellular Component: filamentous actin; stereocilium; microvillus; stereocilium bundle; cytoplasm; dendritic spine; stereocilium bundle tip; cell junction; brush border; actin cytoskeleton

Molecular Function: actin filament binding; SH3 domain binding

Biological Process: positive regulation of filopodium formation; actin filament bundle formation; parallel actin filament bundle formation; sensory perception of sound; actin filament organization; locomotory behavior; negative regulation of cytoskeleton organization and biogenesis

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