Ataxin-10; Brain protein E46 homolog; Spinocerebellar ataxia type 10 protein; ATXN10; SCA10

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

IgG

Rabbit

Antigen Affinity Purified

Liquid

Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.

Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.

Small volumes of anti-ATXN10 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Necessary for the survival of cerebellar neurons. Induces neuritogenesis by activating the Ras-MAP kinase pathway. May play a role in the maintenance of a critical intracellular glycosylation level and homeostasis.

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

Western blot
All lanes: ATXN10 antibody at 4.79ug/ml
Lane 1: A431 whole cell lysate
Lane 2: LO2 whole cell lysate
Lane 3: HepG-2 whole cell lysate
Lane 4: 293T whole cell lysate
Lane 5: Hela whole cell lysate
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 54,47 kDa
Observed band size: 53 kDa

Immunohistochemistry of paraffin-embedded human testis tissue MBS7044359 at dilution 1:100

Immunohistochemistry of paraffin-embedded human ovarian cancer MBS7044359 at dilution 1:100

46,286 Da

ataxin 10

ataxin-10

Ataxin-10

SCA10??[Similar Products]

ATX10_HUMAN

This gene encodes a protein that may function in neuron survival, neuron differentiation, and neuritogenesis. These roles may be carried out via activation of the mitogen-activated protein kinase cascade. Expansion of an ATTCT repeat from 9-32 copies to 800-4500 copies in an intronic region of this locus has been associated with spinocerebellar ataxia, type 10. Alternatively spliced transcript variants have been described.[provided by RefSeq, Jul 2016]

ataxin-10: Necessary for the survival of cerebellar neurons. Induces neuritogenesis by activating the Ras-MAP kinase pathway. May play a role in the maintenance of a critical intracellular glycosylation level and homeostasis. Defects in ATXN10 are the cause of spinocerebellar ataxia type 10 (SCA10). Spinocerebellar ataxia is a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCA10 is an autosomal dominant cerebellar ataxia (ADCA). Defects in ATXN1 may be a cause of nephronophthisis a chronic tubulo-interstitial nephropathy taht leads to anemia, polyuria, polydipsia, isosthenuria and death in uremia. Belongs to the ataxin-10 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell development/differentiation

Chromosomal Location of Human Ortholog: 22q13.31

Cellular Component: cell soma; cytoplasm; dendrite; extracellular space; membrane; perinuclear region of cytoplasm; plasma membrane

Molecular Function: protein binding

Biological Process: nervous system development; neurite development

Disease: Spinocerebellar Ataxia 10

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