Product Name
ATXN10, Polyclonal Antibody
Full Product Name
ATXN10 antibody - C-terminal region
Product Gene Name
anti-ATXN10 antibody
[Similar Products]
Product Synonym Gene Name
E46L; FLJ37990; HUMEEP; SCA10[Similar Products]
Antibody/Peptide Pairs
ATXN10 peptide (MBS3240291) is used for blocking the activity of ATXN10 antibody (MBS3215387)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence
Synthetic peptide located within the following region: LTEDNSQNQD LIAKMEEQGL ADASLLKKVG FEVEKKGEKL ILKSTRDTPK
3D Structure
ModBase 3D Structure for A6NLC4
Species Reactivity
Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat
Purity/Purification
Affinity Purified
Form/Format
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Homology
Cow: 86%; Dog: 79%; Guinea Pig: 93%; Horse: 86%; Human: 100%; Mouse: 77%; Rabbit: 85%; Rat: 93%
Preparation and Storage
For short term use, store at 2-8 degree C up to 1 week. For long term storage, store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
Other Notes
Small volumes of anti-ATXN10 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-ATXN10 antibody
This is a rabbit polyclonal antibody against ATXN10. It was validated on Western Blot
Target Description: This gene encodes a protein that may function in neuron survival, neuron differentiation, and neuritogenesis. These roles may be carried out via activation of the mitogen-activated protein kinase cascade. Expansion of a pentanucleotide repeat in an intronic region of this locus has been associated with spinocerebellar ataxia, type 10. Alternatively spliced transcript variants have been described.
Product Categories/Family for anti-ATXN10 antibody
Polyclonal; Neuro
biology; Developmental Biology; Neuroscience; Disease Related;
Applications Tested/Suitable for anti-ATXN10 antibody
Western Blot (WB)
Western Blot (WB) of anti-ATXN10 antibody
WB Suggested Anti-ATXN10 Antibody
Titration: 1.0 ug/ml
Positive Control: ACHN Whole CellATXN10 is supported by BioGPS gene expression data to be expressed in ACHN
NCBI/Uniprot data below describe general gene information for ATXN10. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001161093
[Other Products]
NCBI GenBank Nucleotide #
NM_001167621
[Other Products]
UniProt Primary Accession #
A6NLC4
[Other Products]
UniProt Related Accession #
Q9UBB4[Other Products]
NCBI Official Full Name
ataxin-10 isoform 2
NCBI Official Synonym Full Names
ataxin 10
NCBI Official Symbol
ATXN10??[Similar Products]
NCBI Official Synonym Symbols
E46L; SCA10; HUMEEP
??[Similar Products]
NCBI Protein Information
ataxin-10
NCBI Summary for ATXN10
This gene encodes a protein that may function in neuron survival, neuron differentiation, and neuritogenesis. These roles may be carried out via activation of the mitogen-activated protein kinase cascade. Expansion of an ATTCT repeat from 9-32 copies to 800-4500 copies in an intronic region of this locus has been associated with spinocerebellar ataxia, type 10. Alternatively spliced transcript variants have been described.[provided by RefSeq, Jul 2016]
Research Articles on ATXN10
1. The 19-CGGC-14 shared haplotype was found in 47% of Brazilian and in 63% of Peruvian families. Frequencies from both are statistically different from Brazilian controls but not Quechua controls. The most frequent haplotype in Quechuas, 19-15-CGGC-14-10, is found in 50% of Brazilian and in 65% of Peruvian patients. The ATTCT expansion may have arisen in a Native American chromosome.
Precautions
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Disclaimer
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