Product Name
ATXN10, Polyclonal Antibody
Full Product Name
Human ATXN10 Polyclonal Antibody
Product Synonym Names
SCA10; Brain protein E46 homolog; Spinocerebellar ataxia type 10 protein
Product Gene Name
anti-ATXN10 antibody
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Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q9UBB4
Species Reactivity
Human, Mouse, Rat
Purity/Purification
Immunogen Affinity Purified
Form/Format
Liquid; 0.1MxPBS, 50% Glycerol, pH7.5
Concentration
200 ug/ml (lot specific)
Immunogen
Recombinant Human ATXN10 Protein
Preparation and Storage
Store at 4 degree C for frequent use. Store at -20 degree C to -70 degree C for 6 months.
Other Notes
Small volumes of anti-ATXN10 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-ATXN10 antibody
Western Blot (WB), Immunohistochemistry (IHC)
NCBI/Uniprot data below describe general gene information for ATXN10. It may not necessarily be applicable to this product.
NCBI GenBank Nucleotide #
NP_037368.1
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UniProt Primary Accession #
Q9UBB4
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NCBI Official Full Name
ataxin-10 isoform 1
UniProt Protein Name
Ataxin-10
UniProt Synonym Protein Names
Brain protein E46 homolog; Spinocerebellar ataxia type 10 protein
UniProt Gene Name
ATXN10??[Similar Products]
UniProt Synonym Gene Names
SCA10??[Similar Products]
UniProt Entry Name
ATX10_HUMAN
UniProt Comments for ATXN10
ataxin-10: Necessary for the survival of cerebellar neurons. Induces neuritogenesis by activating the Ras-MAP kinase pathway. May play a role in the maintenance of a critical intracellular glycosylation level and homeostasis. Defects in ATXN10 are the cause of spinocerebellar ataxia type 10 (SCA10). Spinocerebellar ataxia is a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCA10 is an autosomal dominant cerebellar ataxia (ADCA). Defects in ATXN1 may be a cause of nephronophthisis a chronic tubulo-interstitial nephropathy taht leads to anemia, polyuria, polydipsia, isosthenuria and death in uremia. Belongs to the ataxin-10 family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Cell development/differentiation
Chromosomal Location of Human Ortholog: 22q13.31
Cellular Component: extracellular space; cell soma; membrane; perinuclear region of cytoplasm; cytoplasm; dendrite; plasma membrane; cytosol
Molecular Function: identical protein binding; protein binding
Biological Process: nervous system development; neurite development
Disease: Spinocerebellar Ataxia 10
Precautions
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Disclaimer
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