Full Product Name
Phospho-LRP5 (Tyr1473) Antibody
Product Synonym Names
BMND1; EVR1; EVR4; HBM; Low density lipoprotein receptor related protein 5; Low density lipoprotein receptor related protein 7; Low-density lipoprotein receptor-related protein 5; LR3; LRP-5; Lrp5; LRP5_HUMAN; LRP7; OPPG; OPS; OPTA1; Osteoporosis pseudoglioma syndrome; VBCH2
Product Gene Name
anti-LRP5 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for O75197
Species Reactivity
Human, Mouse, Rat
Purity/Purification
Purified rabbit serum by affinity purification via sequential chromatography on phospho-and non-phospho-peptide affinity columns.
Immunogen
A synthesized peptide derived from human LRP5 around the phosphorylation site of Tyr1473
Storage Buffer
Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Preparation and Storage
Store at -20 degree C. Stable for 12 months from date of receipt.
Other Notes
Small volumes of anti-LRP5 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-LRP5 antibody
Western Blot (WB)
Application Notes for anti-LRP5 antibody
WB: 1:500-1:2000
NCBI/Uniprot data below describe general gene information for LRP5. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001278831.1
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NCBI GenBank Nucleotide #
NM_001291902.1
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UniProt Primary Accession #
O75197
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UniProt Secondary Accession #
Q96TD6; Q9UES7; Q9UP66[Other Products]
UniProt Related Accession #
O75197[Other Products]
NCBI Official Full Name
low-density lipoprotein receptor-related protein 5 isoform 2
NCBI Official Synonym Full Names
LDL receptor related protein 5
NCBI Official Symbol
LRP5??[Similar Products]
NCBI Official Synonym Symbols
HBM; LR3; OPS; EVR1; EVR4; LRP7; OPPG; BMND1; LRP-5; OPTA1; PCLD4; VBCH2
??[Similar Products]
NCBI Protein Information
low-density lipoprotein receptor-related protein 5
UniProt Protein Name
Low-density lipoprotein receptor-related protein 5
Protein Family
Low-density lipoprotein receptor-related protein
UniProt Gene Name
LRP5??[Similar Products]
UniProt Synonym Gene Names
LR3; LRP7; LRP-5??[Similar Products]
NCBI Summary for LRP5
This gene encodes a transmembrane low-density lipoprotein receptor that binds and internalizes ligands in the process of receptor-mediated endocytosis. This protein also acts as a co-receptor with Frizzled protein family members for transducing signals by Wnt proteins and was originally cloned on the basis of its association with type 1 diabetes mellitus in humans. This protein plays a key role in skeletal homeostasis and many bone density related diseases are caused by mutations in this gene. Mutations in this gene also cause familial exudative vitreoretinopathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]
UniProt Comments for LRP5
Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Cell-surface coreceptor of Wnt/beta-catenin signaling, which plays a pivotal role in bone formation. Plays a role in norrin (NDP) signal transduction (PubMed:27228167). The Wnt-induced Fzd/LRP6 coreceptor complex recruits DVL1 polymers to the plasma membrane which, in turn, recruits the AXIN1/GSK3B-complex to the cell surface promoting the formation of signalsomes and inhibiting AXIN1/GSK3-mediated phosphorylation and destruction of beta-catenin. Appears be required for postnatal control of vascular regression in the eye (). Required for posterior patterning of the epiblast during gastrulation ().
Research Articles on LRP5
1. In conclusion, the LRP5 mutation influences cell proliferation through the Wnt signaling pathway, thereby reducing the number of supporting cells and hair cells and leading to nonsyndromic hearing loss in this Chinese family.
Precautions
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Disclaimer
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