Product Name
HGD, cDNA Clone
Popular Item
Full Product Name
HGD cDNA Clone
Product Gene Name
HGD cdna clone
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
atggctgagt taaagtacat ttctggattt gggaatgagt gttcttcaga ggatcctcgc tgcccaggtt ccctgccaga aggacagaat aatcctcagg tctgccccta caatctctat gctgagcagc tctcaggatc ggctttcact tgtccacgga gcaccaataa gagaagctgg ctgtatagga ttctaccttc agtttctcac aagccctttg aatccattga cgaaggccat gtcactcaca actgggatga agttgatcct gatcctaacc agcttagatg gaaaccattt gagattccaa aagcatctca gaagaaagta gactttgtga gtggcctgca taccttgtgt ggagctggag acataaagtc taacaatggg cttgctatcc acattttcct ctgcaatacc tccatggaga acagatgctt ttacaattca gatggggact tcttgattgt tccgcagaaa gggaaccttc tcatttacac cgagtttggc aagatgcttg tacagcccaa tgagatctgc gtcattcaga gaggaatgcg gttcagcata gatgtctttg aggagaccag gggctacatc ttggaggtct atggtgtcca ctttgagtta cctgaccttg gaccaattgg ggccaatggc ttggccaatc ctcgtgattt cttgataccc attgcctggt atgaggatcg ccaagtacca ggtggttaca cggtcattaa taaataccag ggcaagctgt ttgctgccaa acaggatgtc tccccgttca atgttgtggc ctggcacggg aattatacac cctacaagta caacctgaag aatttcatgg ttatcaactc agtggccttt gaccatgcag acccatccat tttcacagta ttgactgcta agtctgtccg ccctggagtg gccattgctg attttgtcat cttcccacct cgatgggggg ttgctgataa gaccttcagg cctccttatt accataggaa ctgcatgagt gagttcatgg gactcatccg aggtcactat gaggcaaagc aaggtgggtt cctgccaggg ggagggagtc tacacagcac aatgaccccc catggacctg atgctgactg ctttgagaag gccagcaagg tcaagctggc acctgagagg attgccgatg gcaccatggc atttatgttt gaatcatctt taagtctggc ggtcacaaag tggggactca aggcctccag gtgtttggat gagaactacc acaagtgctg ggagccactc aagagccact tcactcccaa ctccaggaac ccagcagaac ctaattga
Clone Sequence Report
Provided with product shipment
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of HGD cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for HGD. It may not necessarily be applicable to this product.
NCBI Accession #
BC071757
[Other Products]
UniProt Secondary Accession #
A8K417; B2R8Z0[Other Products]
UniProt Related Accession #
Q93099[Other Products]
Molecular Weight
49,964 Da
NCBI Official Full Name
Homo sapiens homogentisate 1,2-dioxygenase (homogentisate oxidase), mRNA
NCBI Official Synonym Full Names
homogentisate 1,2-dioxygenase
NCBI Official Symbol
HGD??[Similar Products]
NCBI Official Synonym Symbols
AKU; HGO
??[Similar Products]
NCBI Protein Information
homogentisate 1,2-dioxygenase
UniProt Protein Name
Homogentisate 1,2-dioxygenase
UniProt Synonym Protein Names
Homogentisate oxygenase; Homogentisic acid oxidase; Homogentisicase
Protein Family
2-(hydroxymethyl)glutarate dehydrogenase
UniProt Gene Name
HGD??[Similar Products]
UniProt Synonym Gene Names
HGO??[Similar Products]
UniProt Entry Name
HGD_HUMAN
NCBI Summary for HGD
This gene encodes the enzyme homogentisate 1,2 dioxygenase. This enzyme is involved in the catabolism of the amino acids tyrosine and phenylalanine. Mutations in this gene are the cause of the autosomal recessive metabolism disorder alkaptonuria.[provided by RefSeq, May 2010]
UniProt Comments for HGD
HGD: Defects in HGD are the cause of alkaptonuria (AKU). AKU is an autosomal recessive error of metabolism characterized by an increase in the level of homogentisic acid. The clinical manifestations of AKU are urine that turns dark on standing and alkalinization, black ochronotic pigmentation of cartilage and collagenous tissues, and spine arthritis. Belongs to the homogentisate dioxygenase family.
Protein type: Oxidoreductase; EC 1.13.11.5; Amino Acid Metabolism - tyrosine
Chromosomal Location of Human Ortholog: 3q13.33
Cellular Component: cytosol
Molecular Function: homogentisate 1,2-dioxygenase activity; protein binding
Biological Process: L-phenylalanine catabolic process
Disease: Alkaptonuria
Research Articles on HGD
1. A, shows a significant founder effect and high prevalence in a nomadic Indian population.">A novel alkaptonuria mutation, c.87 + 1G > A, shows a significant founder effect and high prevalence in a nomadic Indian population.
Precautions
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Disclaimer
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