Full Product Name
APRIL Polyclonal Antibody
Product Gene Name
anti-APRIL antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for O75888
Other Notes
Small volumes of anti-APRIL antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for APRIL. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001185552.1
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NCBI GenBank Nucleotide #
NM_001198623.1
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UniProt Primary Accession #
O75888
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UniProt Secondary Accession #
Q541E1; Q5U0G8; Q96HV6; Q9P1M8; Q9P1M9; A8MYD5; B4DVT2[Other Products]
UniProt Related Accession #
O75888[Other Products]
Molecular Weight
36,589 Da
NCBI Official Full Name
tumor necrosis factor ligand superfamily member 13 isoform zeta
NCBI Official Synonym Full Names
TNF superfamily member 13
NCBI Official Symbol
TNFSF13??[Similar Products]
NCBI Official Synonym Symbols
APRIL; CD256; TALL2; ZTNF2; TALL-2; TNLG7B; TRDL-1; UNQ383/PRO715
??[Similar Products]
NCBI Protein Information
tumor necrosis factor ligand superfamily member 13
UniProt Protein Name
Tumor necrosis factor ligand superfamily member 13
UniProt Synonym Protein Names
A proliferation-inducing ligand; APRIL; TNF- and APOL-related leukocyte expressed ligand 2; TALL-2; TNF-related death ligand 1; TRDL-1; CD_antigen: CD256
UniProt Gene Name
TNFSF13??[Similar Products]
UniProt Synonym Gene Names
APRIL; TALL2; ZTNF2; APRIL; TALL-2; TRDL-1??[Similar Products]
NCBI Summary for APRIL
The protein encoded by this gene is a member of the tumor necrosis factor (TNF) ligand family. This protein is a ligand for TNFRSF17/BCMA, a member of the TNF receptor family. This protein and its receptor are both found to be important for B cell development. In vitro experiments suggested that this protein may be able to induce apoptosis through its interaction with other TNF receptor family proteins such as TNFRSF6/FAS and TNFRSF14/HVEM. Alternative splicing results in multiple transcript variants. Some transcripts that skip the last exon of the upstream gene (TNFSF12) and continue into the second exon of this gene have been identified; such read-through transcripts are contained in GeneID 407977, TNFSF12-TNFSF13. [provided by RefSeq, Oct 2010]
UniProt Comments for APRIL
Cytokine that binds to TNFRSF13B/TACI and to TNFRSF17/BCMA. Plays a role in the regulation of tumor cell growth. May be involved in monocyte/macrophage-mediated immunological processes.
Research Articles on APRIL
1. The genetic variations and gene expression level of TNFSF13 are associated with the susceptibility and severity of IgA nephropathy in a Han Chinese population.
Precautions
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Disclaimer
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