Full Product Name
HGD Antibody
Product Gene Name
anti-HGD antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Purity/Purification
Affinity purified
Form/Format
PBS, pH 7.4 with 0.02% Sodium Azide
Concentration
1.0 mg/ml (lot specific)
Immunogen Type
Recombinant Protein
Immunogen Description
Recombinant protein
Preparation and Storage
This product is stable for several weeks at 4 degree C as an undiluted liquid. Dilute only prior to immediate use. For extended storage, aliquot contents and freeze at -20 degree C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt.
Other Notes
Small volumes of anti-HGD antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Product Categories/Family for anti-HGD antibody
Total protein Ab
Applications Tested/Suitable for anti-HGD antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
Testing Data of anti-HGD antibody
Testing Data of anti-HGD antibody
NCBI/Uniprot data below describe general gene information for HGD. It may not necessarily be applicable to this product.
NCBI Accession #
NP_000178.2
[Other Products]
NCBI GenBank Nucleotide #
NM_000187.3
[Other Products]
UniProt Secondary Accession #
A8K417; B2R8Z0[Other Products]
UniProt Related Accession #
Q93099[Other Products]
Molecular Weight
49,964 Da
NCBI Official Full Name
homogentisate 1,2-dioxygenase
NCBI Official Synonym Full Names
homogentisate 1,2-dioxygenase
NCBI Official Symbol
HGD??[Similar Products]
NCBI Official Synonym Symbols
AKU; HGO
??[Similar Products]
NCBI Protein Information
homogentisate 1,2-dioxygenase
UniProt Protein Name
Homogentisate 1,2-dioxygenase
UniProt Synonym Protein Names
Homogentisate oxygenase; Homogentisic acid oxidase; Homogentisicase
Protein Family
2-(hydroxymethyl)glutarate dehydrogenase
UniProt Gene Name
HGD??[Similar Products]
UniProt Synonym Gene Names
HGO??[Similar Products]
UniProt Entry Name
HGD_HUMAN
NCBI Summary for HGD
This gene encodes the enzyme homogentisate 1,2 dioxygenase. This enzyme is involved in the catabolism of the amino acids tyrosine and phenylalanine. Mutations in this gene are the cause of the autosomal recessive metabolism disorder alkaptonuria.[provided by RefSeq, May 2010]
UniProt Comments for HGD
HGD: Defects in HGD are the cause of alkaptonuria (AKU). AKU is an autosomal recessive error of metabolism characterized by an increase in the level of homogentisic acid. The clinical manifestations of AKU are urine that turns dark on standing and alkalinization, black ochronotic pigmentation of cartilage and collagenous tissues, and spine arthritis. Belongs to the homogentisate dioxygenase family.
Protein type: Oxidoreductase; EC 1.13.11.5; Amino Acid Metabolism - tyrosine
Chromosomal Location of Human Ortholog: 3q13.33
Cellular Component: cytosol
Molecular Function: homogentisate 1,2-dioxygenase activity; metal ion binding
Biological Process: L-phenylalanine catabolic process; tyrosine catabolic process
Disease: Alkaptonuria
Research Articles on HGD
1. A, shows a significant founder effect and high prevalence in a nomadic Indian population.">A novel alkaptonuria mutation, c.87 + 1G > A, shows a significant founder effect and high prevalence in a nomadic Indian population.
Precautions
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Disclaimer
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