AKU; HGO; Homogentisic Acid Oxidase; Homogentisicase; Homogentisate oxygenase

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

Rabbit

200ug/ml (lot specific)

Manufactured in an ISO 9001:2008 and ISO 13485:2003 Certified Laboratory.

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Small volumes of anti-HGD antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Western Blot (WB), Immunohistochemistry (IHC)

49,964 Da

homogentisate 1,2-dioxygenase

homogentisate 1,2-dioxygenase

Homogentisate 1,2-dioxygenase

HGO??[Similar Products]

This gene encodes the enzyme homogentisate 1,2 dioxygenase. This enzyme is involved in the catabolism of the amino acids tyrosine and phenylalanine. Mutations in this gene are the cause of the autosomal recessive metabolism disorder alkaptonuria.[provided by RefSeq, May 2010]

HGD: Defects in HGD are the cause of alkaptonuria (AKU). AKU is an autosomal recessive error of metabolism characterized by an increase in the level of homogentisic acid. The clinical manifestations of AKU are urine that turns dark on standing and alkalinization, black ochronotic pigmentation of cartilage and collagenous tissues, and spine arthritis. Belongs to the homogentisate dioxygenase family.

Protein type: Amino Acid Metabolism - tyrosine; EC 1.13.11.5; Oxidoreductase

Chromosomal Location of Human Ortholog: 3q13.33

Cellular Component: cytosol

Molecular Function: homogentisate 1,2-dioxygenase activity; identical protein binding; metal ion binding; protein binding

Biological Process: L-phenylalanine catabolic process; tyrosine catabolic process

Disease: Alkaptonuria

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