For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

IgG

Rabbit

The antibody is a rabbit polyclonal antibody raised against HGD. It has been selected for its ability to recognize HGD in immunohistochemical staining andwestern blotting.

Affinity Chromatography

Supplied as solution form in PBS, pH7.4, containing 0.02% NaN3,50% glycerol.

200ug/ml (lot specific)

Store at 4 degree C for frequent use. Stored at -20 degree C to -80 degree C in a manual defrost freezer for one year without detectable loss of activity. Avoid repeated freeze-thaw cycles.

Manufactured in an ISO 9001:2008 and ISO 13485:2003 Certified Laboratory.

Manufactured in a lab with traceable raw materials. Bulk orders can typically be prepared to the customera??s specifications, please inquire.

Small volumes of anti-HGD antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Immunocytochemistry (ICC), Immunohistochemistry (IHC) - Formalin/Paraffin, ELISA (EIA), Western Blot (WB)

Western blotting: 1:100-400
Immunocytochemistry in formalin fixed cells: 1:100-500
Immunohistochemistry in formalin fixed frozen section: 1:100-500
Immunohistochemistry in paraffin section: 1:50-200
Enzyme-linked Immunosorbent Assay: 1:100-200

Western Blot: Sample: Lane1: Mouse Liver Tissue; Lane2: Rat Liver Tissue.

Western Blot: Sample: Recombinant HGD, Mouse.

DAB staining on IHC-P; Samples: Mouse Liver Tissue

DAB staining on IHC-P; Samples: Mouse Kidney Tissue.

49,960 Da

homogentisate 1, 2-dioxygenase

homogentisate 1,2-dioxygenase

Homogentisate 1,2-dioxygenase

Aku; Hgo??[Similar Products]

HGD: Defects in HGD are the cause of alkaptonuria (AKU). AKU is an autosomal recessive error of metabolism characterized by an increase in the level of homogentisic acid. The clinical manifestations of AKU are urine that turns dark on standing and alkalinization, black ochronotic pigmentation of cartilage and collagenous tissues, and spine arthritis. Belongs to the homogentisate dioxygenase family.

Protein type: Amino Acid Metabolism - tyrosine; EC 1.13.11.5; Oxidoreductase

Chromosomal Location of Human Ortholog: 16 B3|16 26.4 cM

Molecular Function: dioxygenase activity; homogentisate 1,2-dioxygenase activity; identical protein binding; metal ion binding; oxidoreductase activity

Biological Process: amino acid metabolic process; L-phenylalanine catabolic process; tyrosine catabolic process; tyrosine metabolic process

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