Product Name
ATP11A, Polyclonal Antibody
Full Product Name
ATP11A Antibody
Product Synonym Names
ATPase class VI type 11A, ATPIH, ATPIS
Product Gene Name
anti-ATP11A antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Species Reactivity
Human, Mouse, Rat
Purity/Purification
Affinity chromatography purified via peptide column
Form/Format
Supplied in PBS containing 0.02% sodium azide.
Immunogen Description
Raised against a 19 amino acid peptide near the amino terminus of human ATP11A.
Preparation and Storage
Can be stored at -20 degree C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Other Notes
Small volumes of anti-ATP11A antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-ATP11A antibody
ATP11A is a widely expressed integral membrane ATPase. ATP11A is probably phosphorylated in its intermediate state and likely drives the transport of ions such as calcium or other molecules across membranes. While the exact molecule ATP11A transports is unknown, increased expression of ATP11A mRNA has been observed in murine leukemia cells made resistant to anti-cancer drugs such as farnesyltransferase inhibitors (FTIs). Furthermore, overexpression of ATP11A provided protection against the FTI SCH66336 while knockdown of ATP11A via siRNA made cells more sensitive to this drug. Other reports suggest that elevated levels of ATP11A mRNA may also be a predictive marker of metastasis in colorectal cancer patients.
Product Categories/Family for anti-ATP11A antibody
Total protein Ab
Applications Tested/Suitable for anti-ATP11A antibody
ELISA (EIA), Western Blot (WB), Immunocytochemistry (ICC)
Western Blot (WB) of anti-ATP11A antibody
Western blot analysis of ATP11A in K562 cell tissue lysate with ATP11A antibody at 1 ug/mL in (A) the absence and (B) the presence of blocking peptide.
Immunocytochemistry (ICC) of anti-ATP11A antibody
Immunocytochemistry of ATP11A in K562 cells with ATP11A antibody at 10 ug/mL.
NCBI/Uniprot data below describe general gene information for ATP11A. It may not necessarily be applicable to this product.
NCBI Accession #
NP_115565
[Other Products]
NCBI GenBank Nucleotide #
NM_032189.3
[Other Products]
UniProt Secondary Accession #
Q5VXT2[Other Products]
UniProt Related Accession #
P98196[Other Products]
Molecular Weight
129,756 Da
NCBI Official Full Name
probable phospholipid-transporting ATPase IH isoform b
NCBI Official Synonym Full Names
ATPase, class VI, type 11A
NCBI Official Symbol
ATP11A??[Similar Products]
NCBI Official Synonym Symbols
ATPIH; ATPIS
??[Similar Products]
NCBI Protein Information
probable phospholipid-transporting ATPase IH
UniProt Protein Name
Probable phospholipid-transporting ATPase IH
UniProt Synonym Protein Names
ATPase IS; ATPase class VI type 11A; P4-ATPase flippase complex alpha subunit ATP11A
Protein Family
Probable phospholipid-transporting ATPase
UniProt Gene Name
ATP11A??[Similar Products]
UniProt Synonym Gene Names
ATPIH; ATPIS; KIAA1021??[Similar Products]
UniProt Entry Name
AT11A_HUMAN
NCBI Summary for ATP11A
The protein encoded by this gene is an integral membrane ATPase. The encoded protein is probably phosphorylated in its intermediate state and likely drives the transport of ions such as calcium across membranes. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Comments for ATP11A
ATP11A: is an integral membrane ATPase. The encoded protein is probably phosphorylated in its intermediate state and likely drives the transport of ions such as calcium across membranes. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Protein type: EC 3.6.3.1; Hydrolase; Transporter; Membrane protein, multi-pass; Transporter, ion channel; Membrane protein, integral
Chromosomal Location of Human Ortholog: 13q34
Cellular Component: recycling endosome; intracellular membrane-bound organelle; membrane; endoplasmic reticulum; lysosomal membrane; early endosome; integral to membrane; plasma membrane
Molecular Function: phospholipid-translocating ATPase activity; protein binding; magnesium ion binding; ATP binding
Biological Process: phospholipid translocation; metabolic process
Research Articles on ATP11A
1. Observational study, meta-analysis, and genome-wide association study of gene-disease association. (HuGE Navigator)
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
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