Full Product Name
OCA2 Antibody
Product Synonym Names
P; BEY; PED; BEY1; BEY2; BOCA; EYCL; HCL3; EYCL2; EYCL3; SHEP1; D15S12
Product Gene Name
anti-OCA2 antibody
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Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Species Reactivity
Human, Mouse
Purity/Purification
Antigen affinity purification
Concentration
1mg/mL (lot specific)
Immunogen
Recombinant protein of human OCA2
Observed Molecular Weight: 92kDa
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3
Preparation and Storage
Store at -20 degree C (regular) and -80 degree C (long term). Avoid freeze / thaw cycles.
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Other Notes
Small volumes of anti-OCA2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-OCA2 antibody
This gene encodes the human homologue of the mouse p (pink-eyed dilution) gene. The encoded protein is believed to be an integral membrane protein involved in small molecule transport, specifically tyrosine - a precursor of melanin. Mutations in this gene result in type 2 oculocutaneous albinism.
Applications Tested/Suitable for anti-OCA2 antibody
Western Blot (WB), Immunohistochemistry (IHC)
Western Blot (WB) of anti-OCA2 antibody
Western blot analysis of extracts of various cell lines, using OCA2 antibody.
NCBI/Uniprot data below describe general gene information for OCA2. It may not necessarily be applicable to this product.
NCBI Accession #
AAH12097.1
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UniProt Secondary Accession #
Q15211; Q15212; Q96EN1; Q9UMI5[Other Products]
UniProt Related Accession #
Q04671[Other Products]
Molecular Weight
74,312 Da
NCBI Official Full Name
OCA2 protein
NCBI Official Synonym Full Names
oculocutaneous albinism II
NCBI Official Symbol
OCA2??[Similar Products]
NCBI Official Synonym Symbols
P; BEY; PED; BEY1; BEY2; BOCA; EYCL; HCL3; EYCL2; EYCL3; SHEP1; D15S12
??[Similar Products]
NCBI Protein Information
P protein; P-protein; eye color 2 (central brown); eye color 3 (brown); hair color 3 (brown); melanocyte-specific transporter protein; oculocutaneous albinism II (pink-eye dilution homolog, mouse); pink-eyed dilution protein homolog; total brown iris pigmentation
UniProt Protein Name
P protein
UniProt Synonym Protein Names
Melanocyte-specific transporter protein; Pink-eyed dilution protein homolog
UniProt Gene Name
OCA2??[Similar Products]
UniProt Synonym Gene Names
D15S12; P??[Similar Products]
UniProt Entry Name
P_HUMAN
NCBI Summary for OCA2
This gene encodes the human homolog of the mouse p (pink-eyed dilution) gene. The encoded protein is believed to be an integral membrane protein involved in small molecule transport, specifically tyrosine, which is a precursor to melanin synthesis. It is involved in mammalian pigmentation, where it may control skin color variation and act as a determinant of brown or blue eye color. Mutations in this gene result in type 2 oculocutaneous albinism. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
UniProt Comments for OCA2
OCA2: a transporer of tyrosine, a precursor for melanin synthesis, within melanocytes. Regulates the pH of melanosomes and melanosome maturation. One of the components of the mammalian pigmentary system. Seems to regulate the postranslational processing of tyrosinase, which catalyzes the limiting reaction in melanin synthesis. May serve as a key control point at which ethnic skin color variation is determined. Major determinant of brown and/or blue eye color. Belongs to the SLC13A transporter family.
Protein type: Membrane protein, integral; Membrane protein, multi-pass; Transporter
Chromosomal Location of Human Ortholog: 15q
Cellular Component: endoplasmic reticulum membrane; lysosomal membrane; melanosome membrane; cytoplasm; integral to membrane; endosome membrane
Molecular Function: protein binding; transporter activity; L-tyrosine transmembrane transporter activity
Biological Process: melanin biosynthetic process; cell proliferation; tyrosine transport; melanocyte differentiation; transmembrane transport; eye pigment biosynthetic process; spermatid development
Disease: Albinism, Oculocutaneous, Type Ii; Skin/hair/eye Pigmentation, Variation In, 1
Research Articles on OCA2
1. REVIEW: current hypotheses and the available data on the mechanism of OCA2 transcriptional regulation and how this is influenced by genetic variation
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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