Polyclonal Claudin 16; Anti-Claudin 16; Claudin 16; Claudin -16; HOMG3; CLDN16; PCLN1

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

Rabbit

Claudin 16 antibody was raised against the C terminal of CLDN16

Affinity purified

Lyophilized powder. Add 50ul distilled water for a 1mg/ml concentration of CLDN16 antibody in PBS

1 mg/ml (lot specific)

Store at 2-8 degree C for short periods. For longer periods of storage, store at -20 degree C. Avoid repeat freeze-thaw cycles.

Small volumes of anti-CLDN16 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Rabbit polyclonal Claudin 16 antibody raised against the C terminal of CLDN16

Cell Biology; Purified Polyclonal Antibodies

Western Blot (WB)

WB: 0.5 ug/ml

Claudin 16 antibody (MBS5300432) used at 0.5 ug/ml to detect target protein.

34 kDa (MW of target protein)[Similar Products]

claudin 16

claudin-16

Claudin-16

PCLN1; PCLN-1??[Similar Products]

CLD16_HUMAN

Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. The protein encoded by this gene, a member of the claudin family, is an integral membrane protein and a component of tight junction strands. It is found primarily in the kidneys, specifically in the thick ascending limb of Henle, where it acts as either an intercellular pore or ion concentration sensor to regulate the paracellular resorption of magnesium ions. Defects in this gene are a cause of primary hypomagnesemia, which is characterized by massive renal magnesium wasting with hypomagnesemia and hypercalciuria, resulting in nephrocalcinosis and renal failure. This gene and the CLDN1 gene are clustered on chromosome 3q28. [provided by RefSeq, Jun 2010]

Claudin-16: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity. Involved in paracellular magnesium reabsorption. Required for a selective paracellular conductance. May form, alone or in partnership with other constituents, an intercellular pore permitting paracellular passage of magnesium and calcium ions down their electrochemical gradients. Alternatively, it could be a sensor of magnesium concentration that could alter paracellular permeability mediated by other factors. Defects in CLDN16 are the cause of hypomagnesemia type 3 (HOMG3); also known as familial hypomagnesemia with hypercalciuria and nephrocalcinosis (FHHNC). HOMG3 is a progressive renal disease characterized by primary renal magnesium wasting with hypomagnesemia, hypercalciuria and nephrocalcinosis. Recurrent urinary tract infections and kidney stones are often observed. In spite of hypercalciuria, patients do not show hypocalcemia. Belongs to the claudin family.

Protein type: Membrane protein, multi-pass; Cell adhesion; Membrane protein, integral

Chromosomal Location of Human Ortholog: 3q28

Cellular Component: tight junction; plasma membrane; integral to membrane

Molecular Function: identical protein binding; protein binding; magnesium ion transmembrane transporter activity; structural molecule activity

Biological Process: cellular metal ion homeostasis; excretion; calcium-independent cell-cell adhesion; magnesium ion transport

Disease: Hypomagnesemia 3, Renal

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