Product Name
Claudin-16 (Cldn16), Recombinant Protein
Full Product Name
Recombinant Mouse Claudin-16 (Cldn16)
Product Gene Name
Cldn16 recombinant protein
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Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Positions
1-235aa; full length protein
Sequence
MKDLLQYAAC FLAIFSTGFL IVATWTDCWM VNADDSLEVS TKCRGLWWEC VTNAFDGIRT CDEYDSIYAE HPLKLVVTRA LMITADILAG FGFITLLLGL DCVKFLPDDP QIKVRLCFVA GTTLLIAGTP GIIGSVWYAV DVYVERSSLV LHNIFLGIQY KFGWSCWLGM AGSLGCFLAG ALLTCCLYLF KDVGPERNYP YAMRKPYSTA GVSMAKSYKA PRTETAKMYA VDTRV
3D Structure
ModBase 3D Structure for Q925N4
Host
Cell Free Expression
Form/Format
Liquid containing glycerol
Storage Buffer
Tris-based buffer, 50% glycerol.
Preparation and Storage
Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.
Repeated freezing and thawing is not recommended. Store working aliquots at 4 degree C for up to one week.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of Cldn16 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Product Categories/Family for Cldn16 recombinant protein
Transmembrane Protein
Application Notes for Cldn16 recombinant protein
This is a recombinant transmembrane protein expressed in a cell-free expression system.
NCBI/Uniprot data below describe general gene information for Cldn16. It may not necessarily be applicable to this product.
NCBI Accession #
NP_444471.1
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NCBI GenBank Nucleotide #
NM_053241.5
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UniProt Primary Accession #
Q925N4
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UniProt Secondary Accession #
Q542L7[Other Products]
UniProt Related Accession #
Q925N4[Other Products]
Molecular Weight
26,100 Da
NCBI Official Full Name
claudin-16
NCBI Official Synonym Full Names
claudin 16
NCBI Official Symbol
Cldn16??[Similar Products]
NCBI Official Synonym Symbols
PCLN1; claudin-16
??[Similar Products]
NCBI Protein Information
claudin-16
UniProt Protein Name
Claudin-16
UniProt Synonym Protein Names
Paracellin-1
UniProt Gene Name
Cldn16??[Similar Products]
UniProt Entry Name
CLD16_MOUSE
NCBI Summary for Cldn16
This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. The protein encoded by this gene is critical for renal paracellular epithelial transport of Ca(2+) and Mg(2+) in the thick ascending loop of Henle. The gene deficiency leads to specific alterations in renal Ca(2+) and Mg(2+) balance and also to disturbances in Na(+) handling. The interaction of this gene and the Cldn 19 gene is required for their assembly into tight junctions and for renal Mg(2+) reabsorption. This gene and the Cldn1 gene are clustered on chromosome 16. [provided by RefSeq, Aug 2010]
UniProt Comments for Cldn16
Claudin-16: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity. Involved in paracellular magnesium reabsorption. Required for a selective paracellular conductance. May form, alone or in partnership with other constituents, an intercellular pore permitting paracellular passage of magnesium and calcium ions down their electrochemical gradients. Alternatively, it could be a sensor of magnesium concentration that could alter paracellular permeability mediated by other factors. Defects in CLDN16 are the cause of hypomagnesemia type 3 (HOMG3); also known as familial hypomagnesemia with hypercalciuria and nephrocalcinosis (FHHNC). HOMG3 is a progressive renal disease characterized by primary renal magnesium wasting with hypomagnesemia, hypercalciuria and nephrocalcinosis. Recurrent urinary tract infections and kidney stones are often observed. In spite of hypercalciuria, patients do not show hypocalcemia. Belongs to the claudin family.
Protein type: Cell adhesion; Membrane protein, multi-pass; Membrane protein, integral
Cellular Component: cell junction; integral to membrane; membrane; plasma membrane; tight junction
Molecular Function: structural molecule activity
Biological Process: ion transport; positive regulation of calcium ion transport; transport
Research Articles on Cldn16
1. 1,25(OH)2 VitD transcriptionally inhibits renal claudin-16 expression by a mechanism sensitive to CaSR and Mg(2+).
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
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