Full Product Name
Anti-CD41 Rabbit pAb
Product Synonym Names
Integrin alpha-Iib; GPalpha Iib; GPIIb; Platelet membrane glycoprotein Iib; CD41; ITGA2B; GP2B; ITGAB
Product Gene Name
anti-CD41 antibody
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Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P08514
Specificity
CD41 Antibody detects endogenous levels of total CD41
Purity/Purification
Affinity Chromatography
Form/Format
Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Immunogen
A synthesized peptide derived from human CD41
Subcellular Location
Membrane; Single-pass type I membrane protein
Preparation and Storage
Store at 4 degree C for short term.
Store at-20 degree C for long term.
Avoid freeze/thaw cycle.
Other Notes
Small volumes of anti-CD41 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-CD41 antibody
Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. It recognizes the sequence R-G-D in a wide array of ligands. It recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain.
Applications Tested/Suitable for anti-CD41 antibody
Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-CD41 antibody
WB: 1:500-1:1000
IHC: 1:50-1:200
Western Blot (WB) of anti-CD41 antibody
Western blot analysis of CD41 expression in human fetal liver lysate.
NCBI/Uniprot data below describe general gene information for CD41. It may not necessarily be applicable to this product.
NCBI Accession #
NP_000410.2
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NCBI GenBank Nucleotide #
NM_000419.4
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UniProt Primary Accession #
P08514
[Other Products]
UniProt Secondary Accession #
O95366; Q14443; Q17R67; B2RCY8[Other Products]
UniProt Related Accession #
P08514[Other Products]
NCBI Official Full Name
integrin alpha-IIb preproprotein
NCBI Official Synonym Full Names
integrin subunit alpha 2b
NCBI Official Symbol
ITGA2B??[Similar Products]
NCBI Official Synonym Symbols
GT; GTA; CD41; GP2B; HPA3; CD41B; GPIIb; BDPLT2; BDPLT16; PPP1R93
??[Similar Products]
NCBI Protein Information
integrin alpha-IIb
UniProt Protein Name
Integrin alpha-IIb
UniProt Synonym Protein Names
GPalpha IIb; GPIIb
UniProt Gene Name
ITGA2B??[Similar Products]
UniProt Synonym Gene Names
GP2B; ITGAB; GPIIb??[Similar Products]
NCBI Summary for CD41
This gene encodes a member of the integrin alpha chain family of proteins. The encoded preproprotein is proteolytically processed to generate light and heavy chains that associate through disulfide linkages to form a subunit of the alpha-IIb/beta-3 integrin cell adhesion receptor. This receptor plays a crucial role in the blood coagulation system, by mediating platelet aggregation. Mutations in this gene are associated with platelet-type bleeding disorders, which are characterized by a failure of platelet aggregation, including Glanzmann thrombasthenia. [provided by RefSeq, Jan 2016]
UniProt Comments for CD41
Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. It recognizes the sequence R-G-D in a wide array of ligands. It recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial cell surface.
Research Articles on CD41
1. this study shows that in the Caucasian population the HPA-3 system confers susceptibility to acute cellular rejection after liver transplantation
Precautions
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Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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