Full Product Name
DBNL antibody - middle region
Product Gene Name
anti-DBNL antibody
[Similar Products]
Product Synonym Gene Name
ABP1; HIP-55; SH3P7[Similar Products]
Antibody/Peptide Pairs
DBNL peptide (MBS3236616) is used for blocking the activity of DBNL antibody (MBS3211668)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence
Synthetic peptide located within the following region: QESAVHPREI FKQKERAMST TSISSPQPGK LRSPFLQKQL TQPETHFGRE
3D Structure
ModBase 3D Structure for Q9UJU6
Species Reactivity
Dog, Guinea Pig, Human, Mouse
Purity/Purification
Affinity Purified
Form/Format
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Homology
Dog: 100%; Guinea Pig: 79%; Human: 100%; Mouse: 86%
Immunogen
The immunogen is a synthetic peptide directed towards the middle region of human DBNL
Preparation and Storage
For short term use, store at 2-8 degree C up to 1 week. For long term storage, store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
Other Notes
Small volumes of anti-DBNL antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-DBNL antibody
This is a rabbit polyclonal antibody against DBNL. It was validated on Western Blot using a cell lysate as a positive control.
Target Description: DBNL is an actin-binding adapter protein. DBNL may act as a common effector of antigen receptor-signaling pathways in leukocytes. Its association with dynamin suggests that it may also connect the actin cytoskeleton to endocytic function. DBNL acts as a k
Product Categories/Family for anti-DBNL antibody
Polyclonal; Various; DNA/RNA/Protein Interactions;
Applications Tested/Suitable for anti-DBNL antibody
Western Blot (WB)
Western Blot (WB) of anti-DBNL antibody
WB Suggested Anti-DBNL Antibody Titration: 0.2-1 ug/ml
Positive Control: Human Muscle
NCBI/Uniprot data below describe general gene information for DBNL. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001014436
[Other Products]
NCBI GenBank Nucleotide #
NM_001014436
[Other Products]
UniProt Primary Accession #
Q9UJU6
[Other Products]
UniProt Related Accession #
Q9UJU6[Other Products]
NCBI Official Full Name
drebrin-like protein isoform b
NCBI Official Synonym Full Names
drebrin like
NCBI Official Symbol
DBNL??[Similar Products]
NCBI Official Synonym Symbols
ABP1; HIP55; SH3P7; HIP-55
??[Similar Products]
NCBI Protein Information
drebrin-like protein
UniProt Protein Name
Drebrin-like protein
UniProt Synonym Protein Names
Cervical SH3P7; Cervical mucin-associated protein; Drebrin-F; HPK1-interacting protein of 55 kDa; HIP-55; SH3 domain-containing protein 7
Protein Family
Drebrin-like protein
UniProt Gene Name
DBNL??[Similar Products]
UniProt Synonym Gene Names
CMAP; SH3P7; HIP-55??[Similar Products]
UniProt Entry Name
DBNL_HUMAN
UniProt Comments for DBNL
DBNL: an SH3-containing adaptor protein. Interacts with hematopoietic progenitor kinase 1a (HIPK1). It is recruited to glycolipid-enriched microdomains following T cell receptor (TCR) stimulation. Interacts with and is phosphorylated by ZAP-70 after TCR signaling. May regulate JNK activation following TCR signaling, presumably via its interaction with HIPKIt is a member of the drebrin family of proteins that are developmentally regulated in the brain.
Protein type: Actin-binding; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 7p13
Cellular Component: Golgi membrane; ruffle; lamellipodium; dendrite; postsynaptic density; cytoplasm; plasma membrane; clathrin coated vesicle membrane; podosome; cell cortex; cytosol; cell junction
Molecular Function: actin filament binding; protein C-terminus binding; protein domain specific binding; protein binding; enzyme activator activity; actin binding
Biological Process: receptor-mediated endocytosis; synaptogenesis; immune system process; apoptosis; Rac protein signal transduction; neurite morphogenesis; activation of JNK activity; cell structure disassembly during apoptosis
Research Articles on DBNL
1. findings show that mAbp1 and FHL2 are novel binding partners that differentially regulate Rho GTPase signaling and MTLn3 breast cancer cell invasion
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
