Product Name
Polycystic kidney disease protein 1-like 1 (PKD1L1), Recombinant Protein
Full Product Name
Recombinant Human Polycystic kidney disease protein 1-like 1 (PKD1L1) , partial
Product Gene Name
PKD1L1 recombinant protein
[Similar Products]
Product Synonym Gene Name
PKD1L1[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q8TDX9
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
>85% (SDS-PAGE) (lot specific)
Form/Format
Liquid containing glycerol
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
Species
Homo sapiens (Human)
Storage Buffer
Tris-based buffer, 50% glycerol
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of PKD1L1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for PKD1L1. It may not necessarily be applicable to this product.
NCBI Accession #
NP_612152.1
[Other Products]
NCBI GenBank Nucleotide #
NM_138295.4
[Other Products]
UniProt Primary Accession #
Q8TDX9
[Other Products]
UniProt Secondary Accession #
Q6UWK1[Other Products]
UniProt Related Accession #
Q8TDX9[Other Products]
Molecular Weight
284,308 Da
NCBI Official Full Name
polycystic kidney disease protein 1-like 1
NCBI Official Synonym Full Names
polycystin 1 like 1, transient receptor potential channel interacting
NCBI Official Symbol
PKD1L1??[Similar Products]
NCBI Official Synonym Symbols
HTX8; PRO19563
??[Similar Products]
NCBI Protein Information
polycystic kidney disease protein 1-like 1
UniProt Protein Name
Polycystic kidney disease protein 1-like 1
UniProt Synonym Protein Names
PC1-like 1 protein; Polycystin-1L1
Protein Family
Polycystic kidney disease
UniProt Gene Name
PKD1L1??[Similar Products]
NCBI Summary for PKD1L1
This gene encodes a member of the polycystin protein family containing 11 transmembrane domains, a receptor for egg jelly (REJ) domain, and a polycystin-1, lipoxygenase, alpha-toxin (PLAT) domain. The encoded protein may play a role in the male reproductive system. Alternative splice variants have been described but their
biological nature has not been determined. [provided by RefSeq, Jul 2008]
UniProt Comments for PKD1L1
Component of a ciliary calcium channel that controls calcium concentration within primary cilia without affecting cytoplasmic calcium concentration. Forms a heterodimer with PKD2L1 in primary cilia and forms a calcium-permeant ciliary channel that regulates sonic hedgehog/SHH signaling and GLI2 transcription. Does not constitute the pore-forming subunit. Also involved in left/right axis specification downstream of nodal flow: forms a complex with PKD2 in cilia to facilitate flow detection in left/right patterning.
Research Articles on PKD1L1
1. The authors report that the human PKD2-L1 selectivity filter is partially selective to calcium ions (Ca(2+)) moving into the cell, but blocked by high internal Ca(2+)concentrations, a unique feature of this transient receptor potential (TRP) channel family member.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
