For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

IgG

Rabbit

>=95% as determined by SDS-PAGE
Immunogen Affinity Purified

Liquid

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20 degree C for 24 months (Avoid repeated freeze / thaw cycles.)

Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.

Small volumes of anti-PPP1R9B antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP)

89,192 Da

protein phosphatase 1 regulatory subunit 9B

neurabin-2

Neurabin-2

PPP1R6??[Similar Products]

NEB2_HUMAN

This gene encodes a scaffold protein that functions as a regulatory subunit of protein phosphatase 1a. Expression of this gene is particularly high in dendritic spines, suggesting that the encoded protein may play a role in receiving signals from the central nervous system. The encoded protein has putative tumor suppressor function and decreased expression has been observed in tumors. [provided by RefSeq, Feb 2014]

Spinophilin: actin-binding regulatory subunit of protein phosphatase 1 (PP1). The actin-binding domain of spinophilin is necessary and sufficient for targeting of spinophilin to dendrites and dendritic spines. May play a role in establishing a signaling complex for dopaminergic neurotransmission through D2 receptors by linking receptors downstream signaling molecules and the actin cytoskeleton. Interacts with p14-ARF. Contains one PDZ/DHR domain.

Protein type: Adaptor/scaffold; Protein phosphatase, regulatory subunit

Chromosomal Location of Human Ortholog: 17q21.33

Cellular Component: actin cytoskeleton; adherens junction; cytoplasm; dendrite; dendritic spine; filopodium; lamellipodium; nucleoplasm; plasma membrane; postsynaptic density; protein phosphatase type 1 complex

Molecular Function: actin filament binding; protein binding; protein phosphatase 1 binding; protein phosphatase inhibitor activity

Biological Process: actin filament organization; calcium-mediated signaling; cell cycle arrest; cell migration; filopodium formation; negative regulation of catalytic activity; negative regulation of cell growth; neurite development; regulation of cell growth by extracellular stimulus; regulation of cell proliferation; regulation of exit from mitosis; regulation of synaptic transmission; RNA splicing

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