Anti -PPP1R9B, NT (PPP1R9B, PPP1R6, Neurabin-2, Protein phosphatase 1 regulatory subunit 9B, Spinophilin, Neurabin-II)

For Research Use Only. Not for use in diagnostic procedures.

Chromosome: 17; NC_000017.10 (48211101..48227877, complement). Location: 17q21.33

Polyclonal

IgG

Rabbit

Human

Affinity Purified
Purified by Protein A affinity chromatography.

Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.

May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Small volumes of anti-PPP1R9B antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Spinophilin is a regulatory subunit of protein phosphatase-1 catalytic subunit (PP1; see MIM 176875) and is highly enriched in dendritic spines, specialized protrusions from dendritic shafts that receive most of the excitatory input in the central nervous system (Allen et al., 1997 [PubMed 9275233]).

Antibodies; Abs to Enzymes, Phosphatase

ELISA (EL/EIA), Western Blot (WB)

Suitable for use in Western Blot, ELISA
Dilution: ELISA: 1:1,000
Western Blot: 1:100-500

89,192 Da[Similar Products]

protein phosphatase 1, regulatory subunit 9B

neurabin-2; neurabin II; neurabin-II; spinophilin; protein phosphatase 1, regulatory (inhibitor) subunit 9B; protein phosphatase 1, regulatory subunit 9B, spinophilin

Neurabin-2

PPP1R6??[Similar Products]

NEB2_HUMAN

Spinophilin is a regulatory subunit of protein phosphatase-1 catalytic subunit (PP1; see MIM 176875) and is highly enriched in dendritic spines, specialized protrusions from dendritic shafts that receive most of the excitatory input in the central nervous system (Allen et al., 1997 [PubMed 9275233]).[supplied by OMIM, Mar 2008]

Spinophilin: actin-binding regulatory subunit of protein phosphatase 1 (PP1). The actin-binding domain of spinophilin is necessary and sufficient for targeting of spinophilin to dendrites and dendritic spines. May play a role in establishing a signaling complex for dopaminergic neurotransmission through D2 receptors by linking receptors downstream signaling molecules and the actin cytoskeleton. Interacts with p14-ARF. Contains one PDZ/DHR domain.

Protein type: Adaptor/scaffold; Protein phosphatase, regulatory subunit

Chromosomal Location of Human Ortholog: 17q21.33

Cellular Component: nucleoplasm; cortical actin cytoskeleton; adherens junction; lamellipodium; cytoplasm; dendritic spine; plasma membrane; synapse; protein phosphatase type 1 complex; filopodium

Molecular Function: protein binding; protein phosphatase inhibitor activity; actin binding; protein phosphatase 1 binding

Biological Process: regulation of synaptic transmission; regulation of cell growth by extracellular stimulus; regulation of protein amino acid phosphorylation; cell migration; filopodium formation; RNA splicing; calcium-mediated signaling; regulation of exit from mitosis; actin filament organization; regulation of cell proliferation; negative regulation of catalytic activity; dendrite development; negative regulation of cell growth; cell cycle arrest

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