Full Product Name
NEB2 Antibody
Product Gene Name
anti-NEB2 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q96SB3
Species Reactivity
Human, Mouse, Rat
Concentration
1.0mg/ml (lot specific)
Other Notes
Small volumes of anti-NEB2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-NEB2 antibody
Western Blot (WB), Immunohistochemistry (IHC)
NCBI/Uniprot data below describe general gene information for NEB2. It may not necessarily be applicable to this product.
NCBI Accession #
NP_115984.3
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NCBI GenBank Nucleotide #
NM_032595.4
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UniProt Primary Accession #
Q96SB3
[Other Products]
UniProt Secondary Accession #
Q8TCR9[Other Products]
UniProt Related Accession #
Q96SB3[Other Products]
Molecular Weight
89,192 Da
NCBI Official Full Name
neurabin-2
NCBI Official Synonym Full Names
protein phosphatase 1 regulatory subunit 9B
NCBI Official Symbol
PPP1R9B??[Similar Products]
NCBI Official Synonym Symbols
Spn; SPINO; PPP1R6; PPP1R9
??[Similar Products]
NCBI Protein Information
neurabin-2
UniProt Protein Name
Neurabin-2
UniProt Synonym Protein Names
Neurabin-II; Protein phosphatase 1 regulatory subunit 9B; Spinophilin
UniProt Gene Name
PPP1R9B??[Similar Products]
UniProt Synonym Gene Names
PPP1R6??[Similar Products]
NCBI Summary for NEB2
This gene encodes a scaffold protein that functions as a regulatory subunit of protein phosphatase 1a. Expression of this gene is particularly high in dendritic spines, suggesting that the encoded protein may play a role in receiving signals from the central nervous system. The encoded protein has putative tumor suppressor function and decreased expression has been observed in tumors. [provided by RefSeq, Feb 2014]
UniProt Comments for NEB2
Spinophilin: actin-binding regulatory subunit of protein phosphatase 1 (PP1). The actin-binding domain of spinophilin is necessary and sufficient for targeting of spinophilin to dendrites and dendritic spines. May play a role in establishing a signaling complex for dopaminergic neurotransmission through D2 receptors by linking receptors downstream signaling molecules and the actin cytoskeleton. Interacts with p14-ARF. Contains one PDZ/DHR domain.
Protein type: Adaptor/scaffold; Protein phosphatase, regulatory subunit
Chromosomal Location of Human Ortholog: 17q21.33
Cellular Component: actin cytoskeleton; cytoplasm; dendrite; filopodium; lamellipodium; nucleoplasm; plasma membrane; postsynaptic density; protein phosphatase type 1 complex
Molecular Function: actin filament binding; protein binding
Biological Process: actin filament organization; calcium-mediated signaling; cell cycle arrest; cell migration; filopodium formation; negative regulation of cell growth; neurite development; regulation of cell growth by extracellular stimulus
Research Articles on NEB2
1. Low spinophilin expression enhances aggressive
biological behavior of breast cancer.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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