Full Product Name
Goat anti-Hes7 Antibody
Product Synonym Names
Hes7; hairy and enhancer of split 7 (Drosophila); bHLHb37; OTTMUSP00000006176; bHLH factor Hes7; mHes7; transcription factor HES-7; Hes7 antibody; hairy and enhancer of split 7 (Drosophila) antibody; bHLHb37 antibody; OTTMUSP00000006176 antibody; bHLH factor Hes7 antibody; mHes7 antibody; transcription factor HES-7 antibody
Product Gene Name
anti-Hes7 antibody
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Antibody/Peptide Pairs
Hes7 peptide (MBS427732) is used for blocking the activity of Hes7 antibody (MBS422894)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence
PRSPGQDAEA LASCY
Species Reactivity
Expected from sequence similarity: Human, Mouse, Rat, Pig, Cow
Purity/Purification
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Form/Format
Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
Concentration
100ug specific antibody in 200ul (lot specific)
Immunogen
Peptide with sequence PRSPGQDAEALASCY, from the internal region of the protein sequence according to NP_149030.2.
Preparation and Storage
Aliquot and store at -20 degree C. Minimize freezing and thawing.
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of anti-Hes7 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-Hes7 antibody
Peptide ELISA (EIA)
Application Notes for anti-Hes7 antibody
Peptide ELISA: Antibody detection limit dilution 1: 16000.
Western Blot: Preliminary experiments in Mouse fetal Liver and fetal Skeletal Muscle lysates gave no specific signal but low background (at antibody concentration up to 1ug/ml).
NCBI/Uniprot data below describe general gene information for Hes7. It may not necessarily be applicable to this product.
NCBI Accession #
NP_149030.2
[Other Products]
NCBI GenBank Nucleotide #
NM_033041.4
[Other Products]
UniProt Secondary Accession #
Q99JA6; A3KPD3[Other Products]
UniProt Related Accession #
Q8BKT2[Other Products]
Molecular Weight
24,890 Da
NCBI Official Full Name
transcription factor HES-7
NCBI Official Synonym Full Names
hairy and enhancer of split 7 (Drosophila)
NCBI Official Symbol
Hes7??[Similar Products]
NCBI Official Synonym Symbols
bHLHb37
??[Similar Products]
NCBI Protein Information
transcription factor HES-7
UniProt Protein Name
Transcription factor HES-7
UniProt Synonym Protein Names
Hairy and enhancer of split 7; bHLH factor Hes7
Protein Family
Transcription factor
UniProt Gene Name
Hes7??[Similar Products]
UniProt Synonym Gene Names
mHes7??[Similar Products]
UniProt Entry Name
HES7_MOUSE
UniProt Comments for Hes7
HES7: Transcriptional repressor. Represses transcription from both N box- and E box-containing promoters. May with HES1, cooperatively regulate somite formation in the presomitic mesoderm (PSM). May function as a segmentation clock, which is essential for coordinated somite segmentation. Defects in HES7 are the cause of spondylocostal dysostosis type 4 (SCDO4). A rare condition of variable severity characterized by vertebral and costal anomalies. The main feature include dwarfism, vertebral fusion, hemivertebrae, posterior rib fusion, reduced rib number, and other rib malformations.
Cellular Component: nucleus
Molecular Function: DNA binding; protein dimerization activity; transcription factor binding
Biological Process: multicellular organismal development; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; Notch signaling pathway; regulation of somitogenesis; regulation of transcription, DNA-dependent; rhythmic process; skeletal development; somitogenesis; transcription, DNA-dependent
Research Articles on Hes7
1. Lengthening the third Hes7 intron by 10 or 20 kb disrupts accurate RNA splicing and inactivates the gene.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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