Product Name
Werner syndrome ATP-dependent helicase homolog (wrn), Recombinant Protein
Full Product Name
Recombinant Xenopus laevis Werner syndrome ATP-dependent helicase homolog (wrn), partial
Product Gene Name
wrn recombinant protein
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for O93530
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
>85% (SDS-PAGE) (lot specific)
Form/Format
Liquid containing glycerol
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
Species
Xenopus laevis (African clawed frog)
Storage Buffer
Tris-based buffer, 50% glycerol
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of wrn recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for wrn. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001081838.1
[Other Products]
NCBI GenBank Nucleotide #
NM_001088369.1
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UniProt Primary Accession #
O93530
[Other Products]
UniProt Related Accession #
O93530[Other Products]
Molecular Weight
161,851 Da
NCBI Official Full Name
Werner syndrome ATP-dependent helicase homolog
NCBI Official Synonym Full Names
Werner syndrome, RecQ helicase-like L homeolog
NCBI Official Symbol
wrn.L??[Similar Products]
NCBI Official Synonym Symbols
wrn; xwrn; ffa-1
??[Similar Products]
NCBI Protein Information
Werner syndrome ATP-dependent helicase homolog
UniProt Protein Name
Werner syndrome ATP-dependent helicase homolog
UniProt Synonym Protein Names
Exonuclease WRN (EC:3.1.-.-); Focus-forming activity 1; FFA-1
Protein Family
Werner syndrome ATP-dependent helicase
UniProt Gene Name
wrn??[Similar Products]
UniProt Synonym Gene Names
ffa1; FFA-1??[Similar Products]
UniProt Comments for wrn
Multifunctional enzyme that has both magnesium and ATP-dependent DNA-helicase activity and 3'->5' exonuclease activity towards double-stranded DNA with a 5'-overhang. Has no nuclease activity towards single-stranded DNA or blunt-ended double-stranded DNA. Binds preferentially to DNA substrates containing alternate secondary structures, such as replication forks and Holliday junctions. May play an important role in the dissociation of joint DNA molecules that can arise as products of homologous recombination, at stalled replication forks or during DNA repair. Alleviates stalling of DNA polymerases at the site of DNA lesions. Important for genomic integrity. Plays a role in the formation of DNA replication focal centers; stably associates with foci elements generating s for RP-A ().
Research Articles on wrn
1. Xenopus Werner syndrome protein (xWRN)-mediated end processing is remarkably similar to the end processing that has been proposed for the Escherichia coli RecQ helicase and RecJ single-strand nuclease
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
