Rat Peroxisomal multifunctional enzyme type 2 (HSD17B4) ELISA kit; DBP; MFE-2; SDR8C1; 17-beta-HSD IV; 17-beta-hydroxysteroid dehydrogenase 4; 17beta-estradiol dehydrogenase type IV; 3-alpha; 7-alpha; 12-alpha-trihydroxy-5-beta-cholest-24-enoyl-CoA hydratase; D-3-hydroxy; hydroxysteroid (17-beta) dehydrogenase 4

For Research Use Only. Not for use in diagnostic procedures.

Store all reagents at 2-8 degree C

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Small volumes of HSD17B4 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS9339574 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the hydroxysteroid (17-beta) dehydrogenase 4 (HSD17B4) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing HSD17B4. The ELISA analytical biochemical technique of the MBS9339574 kit is based on HSD17B4 antibody-HSD17B4 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect HSD17B4 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, HSD17B4. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

79,428 Da

hydroxysteroid (17-beta) dehydrogenase 4

peroxisomal multifunctional enzyme type 2; DBP; MFE-2; 17-beta-HSD 4; D-bifunctional protein; multifunctional protein 2; 17-beta-hydroxysteroid dehydrogenase 4; peroxisomal multifunctional enzyme type II

Peroxisomal multifunctional enzyme type 2

Edh17b4; MFE-2; 17-beta-HSD 4; DBP; MPF-2??[Similar Products]

DHB4_RAT

a 17 beta-hydroxysteroid dehydrogenase type IV involved in cholesterol metabolism [RGD, Feb 2006]

HSD17B4: Bifunctional enzyme acting on the peroxisomal beta- oxidation pathway for fatty acids. Catalyzes the formation of 3- ketoacyl-CoA intermediates from both straight-chain and 2-methyl- branched-chain fatty acids. Defects in HSD17B4 are a cause of D-bifunctional protein deficiency (DBPD). DBPD is a disorder of peroxisomal fatty acid beta-oxidation. Defects in HSD17B4 are the cause of Perrault syndrome (PRS). PRS is a sex-influenced disorder characterized by sensorineural deafness in both males and females and ovarian dysgenesis in females. Some patients also have neurologic manifestations, including mild mental retardation and cerebellar and peripheral nervous system involvement. Belongs to the short-chain dehydrogenases/reductases (SDR) family.

Protein type: Cell development/differentiation; EC 1.1.1.n12; Mitochondrial; Lipid Metabolism - primary bile acid biosynthesis; EC 4.2.1.119; EC 4.2.1.107; Lyase; Oxidoreductase

Cellular Component: peroxisomal membrane; intracellular membrane-bound organelle; mitochondrion; membrane; peroxisome

Molecular Function: 3(or 17)beta-hydroxysteroid dehydrogenase activity; protein homodimerization activity; 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA hydratase activity; isomerase activity; long-chain-enoyl-CoA hydratase activity; 3-hydroxyacyl-CoA dehydrogenase activity; receptor binding

Biological Process: osteoblast differentiation; cholesterol metabolic process; estrogen metabolic process; fatty acid beta-oxidation; metabolic process; very-long-chain fatty acid metabolic process; androgen metabolic process; Sertoli cell development

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