Full Product Name
GPSM2 Antibody (N-Term)
Product Synonym Names
Purified Rabbit Polyclonal Antibody (Pab); G-protein-signaling modulator 2; Mosaic protein LGN; GPSM2; LGN
Product Gene Name
anti-GPSM2 antibody
[Similar Products]
Antibody/Peptide Pairs
GPSM2 peptide (MBS9230446) is used for blocking the activity of GPSM2 antibody (MBS9216836)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P81274
Species Reactivity
Human
Predicted: Mouse
Specificity
This GPSM2 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 113-143 amino acids from human GPSM2.
Form/Format
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
Other Notes
Small volumes of anti-GPSM2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-GPSM2 antibody
Plays an important role in spindle pole orientation. Interacts and contributes to the functional activity of G(i) alpha proteins. Acts to stabilize the apical complex during neuroblast divisions.
Product Categories/Family for anti-GPSM2 antibody
Cell Biology; Signal Transduction
Applications Tested/Suitable for anti-GPSM2 antibody
Western Blot (WB)
Application Notes for anti-GPSM2 antibody
WB ~~ 1:2000
Western Blot (WB) of anti-GPSM2 antibody
All lanes : Anti-GPSM2 Antibody (N-Term) at 1:2000 dilution
Lane 1: U-2OS whole cell lysate
Lane 2: A431 whole cell lysate
Lysates/proteins at 20 ug per lane.
Secondary
Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution.
Predicted band size : 77 kDa
Blocking/Dilution buffer: 5% NFDM/TBST.
NCBI/Uniprot data below describe general gene information for GPSM2. It may not necessarily be applicable to this product.
NCBI Accession #
NP_037428.3
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NCBI GenBank Nucleotide #
NM_013296.4
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UniProt Primary Accession #
P81274
[Other Products]
UniProt Secondary Accession #
Q5T1N8; Q6IBL7; Q8N0Z5[Other Products]
UniProt Related Accession #
P81274[Other Products]
NCBI Official Full Name
G-protein-signaling modulator 2
NCBI Official Synonym Full Names
G-protein signaling modulator 2
NCBI Official Symbol
GPSM2??[Similar Products]
NCBI Official Synonym Symbols
LGN; CMCS; PINS; DFNB82
??[Similar Products]
NCBI Protein Information
G-protein-signaling modulator 2
UniProt Protein Name
G-protein-signaling modulator 2
UniProt Synonym Protein Names
Mosaic protein LGN
Protein Family
G-protein-signaling modulator
UniProt Gene Name
GPSM2??[Similar Products]
UniProt Synonym Gene Names
LGN??[Similar Products]
UniProt Entry Name
GPSM2_HUMAN
NCBI Summary for GPSM2
The protein encoded by this gene belongs to a family of proteins that modulate activation of G proteins, which transduce extracellular signals received by cell surface receptors into integrated cellular responses. The N-terminal half of this protein contains 10 copies of leu-gly-asn (LGN) repeat, and the C-terminal half contains 4 GoLoco motifs, which are involved in guanine nucleotide exchange. This protein may play a role in neuroblast division and in the development of normal hearing. Mutations in this gene are associated with autosomal recessive nonsyndromic deafness (DFNB82).[provided by RefSeq, Jan 2011]
UniProt Comments for GPSM2
GPSM2: Plays an important role in spindle pole orientation. Interacts and contributes to the functional activity of G(i) alpha proteins. Acts to stabilize the apical complex during neuroblast divisions. Interacts with LLGL2. Interacts with INSC/inscuteable and probably with F2RL2. Ubiquitously expressed. Belongs to the GPSM family.
Protein type: G protein regulator, misc.
Chromosomal Location of Human Ortholog: 1p13.3
Cellular Component: apical part of cell; cytoplasm; cell cortex
Molecular Function: identical protein binding; protein binding; GTPase regulator activity
Biological Process: G-protein coupled receptor protein signaling pathway; establishment of mitotic spindle orientation; regulation of catalytic activity
Disease: Chudley-mccullough Syndrome
Product References and Citations for anti-GPSM2 antibody
Mochizuki N.,et al.Gene 181:39-43(1996).
Katagiri T.,et al.Submitted (JUL-2008) to the EMBL/GenBank/DDBJ databases.
Gregory S.G.,et al.Nature 441:315-321(2006).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
Puhl H.L. III,et al.Submitted (JUL-2002) to the EMBL/GenBank/DDBJ databases.
Research Articles on GPSM2
1. A crystal structure of Frmpd4-bound LGN in an oxidized form is also reported, although oxidation does not appear to strongly affect the interaction with Frmpd4.
Precautions
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Disclaimer
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