Recombinant Human GM-CSF (CSF2)
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產(chǎn)品名稱: Recombinant Human GM-CSF (CSF2)
產(chǎn)品型號(hào): Z100275
產(chǎn)品展商: 其他品牌
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Recombinant Human GM-CSF (CSF2)
Recombinant Human GM-CSF (CSF2)
的詳細(xì)介紹
|
Print Version |
| Alternative Names |
GM-CSF, Granulocyte-macrophage colony-stimulating factor, CSF-2, Pluripoietin-alpha, Recombinant Human Granulocyte Macrophage Colony Stimulating Factor (CSF2) |
| Description |
GM-CSF is a hematopoietic growth factor that is produced by endothelial cells, monocytes, fibroblasts and T-lymphocytes following their activation by antigens or mitogens. GM-CSF stimulates the development of macrophages and neutrophils and plays a role in the proliferation and development of early erythroid megakaryocytic and eosinophilic progenitor cells. Approximately 90% of the secreted colony stimulating activities are due to GM-CSF. While non-glycosylated and glycosylated GM-CSF show similar activities in vitro, fully glycosylated GM-CSF is biologically more active in vivo compared to its non-glycosylated counterpart. Human and murine GM-CSF are species-specific and therefore, exhibit no cross-reactivity. Recombinant Human GM-CSF is a non-glycosylated, monomeric protein that contains intra-chain disulfide bonds. |
| Gene Symbol |
CSF2 |
| Gene ID |
1437 |
| Accession No. |
P04141 |
| Source |
E. coli |
| Appearance |
Lyophilized Powder |
| Molecular Weight |
15.0 kDa |
| Endotoxin Level |
<1.0 EU/μg of recombinant protein as determined by the LAL method |
| Purity |
>95% as determined by SDS-PAGE |
| Gel Image |
 |
| Bioactivity |
The ED50 as determined by the dose-dependent stimulation of the proliferation of human TF-1 cells was found to be ≤ 0.5 ng/mL |
| Bioactivity Data |
 |
| Formulation |
Lyophilized from a 0.2 μm filtered solution in Tris and NaCl |
| Reconstitution |
A quick spin of the vial followed by reconstitution in distilled water to a concentration not less than 0.1 mg/mL. This solution can then be diluted into other buffers. |
| Storage |
The lyophilized protein is stable for at least one year from date of receipt at -70°C. Upon reconstitution, this cytokine can be stored in working aliquots at 2° - 8°C for one month, or at -20°C for six months, with a carrier protein without detectable loss of activity. Avoid repeated freeze/thaw cycles. |
| Usage |
For research use only. Not for diagnostic or therapeutic use. |
