Anti-Human p75NTR Antibody
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產(chǎn)品名稱: Anti-Human p75NTR Antibody
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簡單介紹
Anti-Human p75NTR Antibody
的詳細介紹
| Overview |
Print Version
|
| Product Name |
Anti-Human p75NTR Antibody |
| Description |
Nerve growth factor receptor (NGFR) is also referred to as p75(NTR) due to its molecular mass and its ability to bind at low affinity not only NGF (see 162030), but also other neurotrophins, including brain-derived neurotrophic factor (BDNF; 113505), neurotrophin-3 (NTF3; 162660), and neurotrophin-4/5 (NTF5; 162662). At the time of its discovery, NGFR was considered a unique type of protein. Subsequently, however, a large superfamily of tumor necrosis factor receptors were found to share the overall structure of NGFR (4 extracellular ligand-binding, cysteine-rich repeats, or CRs, and signaling through association with, or disassociation from, cytoplasmic interactors). The identification of this superfamily helped elucidate some of the biologic functions of NGFR, including its ultimate involvement in the nuclear factor kappa-B (NFKB; see 164011) and apoptosis pathways. As a monomer, NGFR binds NGF with low affinity. Higher affinity binding is achieved by association with higher molecular mass, low-affinity neurotrophin receptors, namely the tropomyosin receptor kinases, TRKA (NTRK1; 191315), TRKB (NTRK2; 600456), and TRKC (NTRK3; 191316). TRKA, TRKB, and TRKC are specific for or 'preferred by' NGF, NTF5 and BDNF, and NTF3, respectively (Ip et al., 1993). NTF3 also binds to TRKA and TRKB, but with significantly lower affinity |
| Subtype |
monoclonal |
| Application |
IHC,ICC/IF,Flow Cyt |
| Raised In |
mouse |
| Specificity |
This antibody recognises p75NTR (low affinity neurotrophin receptor) |
| Immunogen |
The p75NTR antibody was derived from immunization of mice with human WM245 melanoma cells. |
| Guarantee |
abm guarantees that all our Anti-Human p75NTR Antibody will perform as described on this product webpage, if this is not the case we will provide you with a one-time replacement at no extra cost. Documentation and explanation of experiment conducted will be required when submitting a claim for replacement. |
| Properties |
|
| Formulation |
Liquid |
| Quantity |
50 μl |
| Clone |
Monoclonal |
| Storage |
This product is stable for several weeks at 4°C as an undiluted liquid. Dilute only prior to immediate use. For extended storage, aliquot contents and freeze at -20°C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt. |
| Storage Buffer |
PBS, pH 7.4 with 0.02% sodium azide. |
| Concentration |
1μg/ul |
| Purity |
Protein G Purified |
| Isotype |
IgG |
| Species Reactivity |
human,rat,sheep,other |
| Specific References |
|
Y075010 has been referenced in 1 publication.
-
1.Walker BR et al. (2007) Behav Brain Res 176:109-20
|
