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7,8-Dihydro-8-Oxoguanine Triphosphatase (NUDT1) Antibody

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產(chǎn)品名稱: 7,8-Dihydro-8-Oxoguanine Triphosphatase (NUDT1) Antibody
產(chǎn)品型號(hào): abx004194
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7,8-Dihydro-8-Oxoguanine Triphosphatase (NUDT1) Antibody


7,8-Dihydro-8-Oxoguanine Triphosphatase (NUDT1) Antibody  的詳細(xì)介紹
NUDT1 Antibody is a Rabbit Polyclonal antibody against NUDT1. Misincorporation of oxidized nucleoside triphosphates into DNA/RNA during replication and transcription can cause mutations that may result in carcinogenesis or neurodegeneration. The protein encoded by this gene is an enzyme that hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP, 8-oxo-dATP, 2-hydroxy-dATP, and 2-hydroxy rATP, to monophosphates, thereby preventing misincorporation. The encoded protein is localized mainly in the cytoplasm, with some in the mitochondria, suggesting that it is involved in the sanitization of nucleotide pools both for nuclear and mitochondrial genomes. Several alternatively spliced transcript variants, some of which encode distinct isoforms, have been identified. Additional variants have been observed, but their full-length natures have not been determined. A single-nucleotide polymorphism that results in the production of an additional, longer isoform (p26) has been described.

Target NUDT1
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Tested Applications WB, IHC
Recommended dilutions WB: 1/500 - 1/2000, IHC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user.
Immunogen Recombinant protein of human NUDT1.
Purification Affinity purified.
Form Liquid
Isotype IgG
Conjugation Unconjugated
Storage Aliquot and store at -20 °C. Avoid repeated freeze/thaw cycles.
Molecular Weight Calculated MW: 17 kDa/19 kDa/20 kDa/22 kDa
Observed MW: 18 kDa
Swiss Prot P36639
GeneID 4521
Gene Symbol NUDT1
Concentration > 1 mg/ml
Buffer PBS, pH 7.3, 0.02% sodium azide, 50% glycerol.
UNSPSC Code 12352203
Availability Shipped within 5-10 working days.
Note This product is for research use only.
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