7,8-Dihydro-8-Oxoguanine Triphosphatase (NUDT1) Antibody
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產(chǎn)品名稱: 7,8-Dihydro-8-Oxoguanine Triphosphatase (NUDT1) Antibody
產(chǎn)品型號(hào): abx004194
產(chǎn)品展商: 其他品牌
產(chǎn)品文檔: 無相關(guān)文檔
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7,8-Dihydro-8-Oxoguanine Triphosphatase (NUDT1) Antibody
7,8-Dihydro-8-Oxoguanine Triphosphatase (NUDT1) Antibody
的詳細(xì)介紹
NUDT1 Antibody is a Rabbit Polyclonal antibody against NUDT1. Misincorporation of oxidized nucleoside triphosphates into DNA/RNA during replication and transcription can cause mutations that may result in carcinogenesis or neurodegeneration. The protein encoded by this gene is an enzyme that hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP, 8-oxo-dATP, 2-hydroxy-dATP, and 2-hydroxy rATP, to monophosphates, thereby preventing misincorporation. The encoded protein is localized mainly in the cytoplasm, with some in the mitochondria, suggesting that it is involved in the sanitization of nucleotide pools both for nuclear and mitochondrial genomes. Several alternatively spliced transcript variants, some of which encode distinct isoforms, have been identified. Additional variants have been observed, but their full-length natures have not been determined. A single-nucleotide polymorphism that results in the production of an additional, longer isoform (p26) has been described.
| Target |
NUDT1 |
| Reactivity |
Human, Mouse, Rat |
| Host |
Rabbit |
| Clonality |
Polyclonal |
| Tested Applications |
WB, IHC |
| Recommended dilutions |
WB: 1/500 - 1/2000, IHC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Immunogen |
Recombinant protein of human NUDT1. |
| Purification |
Affinity purified. |
| Form |
Liquid |
| Isotype |
IgG |
| Conjugation |
Unconjugated |
| Storage |
Aliquot and store at -20 °C. Avoid repeated freeze/thaw cycles. |
| Molecular Weight |
Calculated MW: 17 kDa/19 kDa/20 kDa/22 kDa
Observed MW: 18 kDa |
| Swiss Prot |
P36639
|
| GeneID |
4521
|
| Gene Symbol |
NUDT1 |
| Concentration |
> 1 mg/ml |
| Buffer |
PBS, pH 7.3, 0.02% sodium azide, 50% glycerol. |
| UNSPSC Code |
12352203 |
| Availability |
Shipped within 5-10 working days. |
| Note |
This product is for research use only. |
