Activating Molecule In BECN1-Regulated Autophagy Protein 1 (AMBRA1) Antibody
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產(chǎn)品名稱: Activating Molecule In BECN1-Regulated Autophagy Protein 1 (AMBRA1) Antibody
產(chǎn)品型號(hào): abx001006
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Activating Molecule In BECN1-Regulated Autophagy Protein 1 (AMBRA1) Antibody
Activating Molecule In BECN1-Regulated Autophagy Protein 1 (AMBRA1) Antibody
的詳細(xì)介紹
AMBRA1 Antibody is a Rabbit Polyclonal antibody against AMBRA1. WD-repeats are motifs that are found in a variety of proteins and are characterized by a conserved core of 40-60 amino acids that commonly form a tertiary propeller structure. While proteins that contain WD-repeats participate in a wide range of cellular functions, they are generally involved in regulatory mechanisms concerning chromatin assembly, cell cycle control, signal transduction, RNA processing, apoptosis and vesicular trafficking. AMBRA1 (Activating molecule in BECN1-regulated autophagy protein 1), also known as WDR94 or KIAA1736, is a 1,298 amino acid protein that contains three WD repeats. Localized to cytoplasmic vesicles, AMBRA1 functions to control protein turnover, cell proliferation and cell survival during neuronal development, thereby playing an important role in autophagy and the development of the nervous system. Multiple isoforms of AMBRA1 exist due to alternative spicing events.
| Target |
AMBRA1 |
| Reactivity |
Human, Mouse, Rat |
| Host |
Rabbit |
| Clonality |
Polyclonal |
| Tested Applications |
WB, IHC |
| Recommended dilutions |
WB: 1/500 - 1/2000, IHC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Immunogen |
Recombinant protein of human AMBRA1. |
| Purification |
Affinity purified. |
| Form |
Liquid |
| Isotype |
IgG |
| Conjugation |
Unconjugated |
| Storage |
Aliquot and store at -20 °C. Avoid repeated freeze/thaw cycles. |
| Molecular Weight |
Calculated MW: 84 kDa/132 kDa/135 kDa/139 kDa/142 kDa
Observed MW: 140 kDa |
| Swiss Prot |
Q9C0C7
|
| GeneID |
55626
|
| Gene Symbol |
AMBRA1 |
| Concentration |
> 1 mg/ml |
| Buffer |
PBS, pH 7.3, 0.02% sodium azide, 50% glycerol. |
| UNSPSC Code |
12352203 |
| Availability |
Shipped within 5-10 working days. |
| Note |
This product is for research use only. |
