Caspase Recruitment Domain Family Member 8 (CARD8) Antibody
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產品名稱: Caspase Recruitment Domain Family Member 8 (CARD8) Antibody
產品型號: abx000674
產品展商: 其他品牌
產品文檔: 無相關文檔
簡單介紹
Caspase Recruitment Domain Family Member 8 (CARD8) Antibody
Caspase Recruitment Domain Family Member 8 (CARD8) Antibody
的詳細介紹
CARD8 Antibody is a Rabbit Polyclonal antibody against CARD8. The protein encoded by this gene belongs to the caspase recruitment domain (CARD)-containing family of proteins, which are involved in pathways leading to activation of caspases or nuclear factor kappa-B (NFKB). This protein may be a component of the inflammasome, a protein complex that plays a role in the activation of proinflammatory caspases. It is thought that this protein acts as an adaptor molecule that negatively regulates NFKB activation, CASP1-dependent IL1B secretion, and apoptosis. Polymorphisms in this gene may be associated with a susceptibility to rheumatoid arthritis. Alternatively spliced transcript variants have been described for this gene, but their biological validity has not been determined. [provided by RefSeq].
| Target |
CARD8 |
| Reactivity |
Human, Mouse, Rat |
| Host |
Rabbit |
| Clonality |
Polyclonal |
| Tested Applications |
WB |
| Recommended dilutions |
WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user. |
| Immunogen |
Recombinant protein of human CARD8. |
| Purification |
Affinity purified. |
| Form |
Liquid |
| Isotype |
IgG |
| Conjugation |
Unconjugated |
| Storage |
Aliquot and store at -20 °C. Avoid repeated freeze/thaw cycles. |
| Molecular Weight |
Calculated MW: 32 kDa/44 kDa/48 kDa/55 kDa/60 kDa
Observed MW: 55 kDa |
| Swiss Prot |
Q9Y2G2
|
| GeneID |
22900
|
| Gene Symbol |
CARD8 |
| Concentration |
> 1 mg/ml |
| Buffer |
PBS, pH 7.3, 0.02% sodium azide, 50% glycerol. |
| UNSPSC Code |
12352203 |
| Availability |
Shipped within 5-10 working days. |
| Note |
This product is for research use only. |
