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產(chǎn)品名稱: CDC25A (pS75) Antibody
產(chǎn)品型號: abx010536
產(chǎn)品展商: 其他品牌
產(chǎn)品文檔: 無相關(guān)文檔
簡單介紹
CDC25A (pS75) Antibody
的詳細(xì)介紹
Phospho-CDC25A (Ser75) Antibody detects endogenous levels of CDC25A only when phosphorylated at Sersine 75. CDC25A is a member of the CDC25 family of phosphatases. CDC25A is required for progression from G1 to the S phase of the cell cycle. It activates the cyclin-dependent kinase CDC2 by removing two phosphate groups. CDC25A is specifically degraded in response to DNA damage, which prevents cells with chromosomal abnormalities from progressing through cell division. CDC25A is an oncogene, although its exact role in oncogenesis has not been demonstrated. Two transcript variants encoding different isoforms have been found for this gene.
| Target |
CDC25A (pS75) |
| Reactivity |
Human, Mouse, Rat |
| Host |
Rabbit |
| Clonality |
Polyclonal |
| Tested Applications |
WB |
| Recommended dilutions |
Optimal dilutions/concentrations should be determined by the end user. |
| Purification |
Purified by affinity chromatography. |
| Conjugation |
Unconjugated |
| Storage |
Aliquot and store at -20 °C. Avoid repeated freeze/thaw cycles. |
| Swiss Prot |
P30304
|
| GeneID |
993
|
| Gene Symbol |
CDC25A |
| OMIM |
116947
|
| Enzyme Commission Number |
EC 3.1.3.48 |
| HGNC |
1725 |
| Ensembl |
ENSG00000164045 |
| Buffer |
PBS, pH 7.4, 150 mM NaCl, 0.02% sodium azide and 50% glycerol. |
| UNSPSC Code |
12352203 |
| Availability |
Shipped within 5-10 working days. |
| Note |
This product is for research use only. |
