APC - anti human CD80 - Clone MEM-233
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產(chǎn)品名稱: APC - anti human CD80 - Clone MEM-233
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APC - anti human CD80 - Clone MEM-233
APC - anti human CD80 - Clone MEM-233
的詳細(xì)介紹
APC
- anti Human
CD80 - MEM-233
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MEM-233
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IgG1
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FCM
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APC
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Please refer to the Certificate of Analysis for the lot-specific concentration.
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Human CD80
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Human
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The reagent is provided in aqueous buffered solution containing protein stabilizer, and ≤0.09% sodium azide (NaN3)
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RUO
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CD80, clone MEM-233, is a mAb intended for identification of human circulating neutrophils. This reagent is effective for direct IF staining of human tissue for FCM analysis using ≤1 μg/106 cells.
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This antibody reacts with the CD80-antigen, which is a 60 kD single chain type I glycoprotein belonging to the immunoglobulin superfamily. CD80 is expressed on activated B and T cells, macrophages, and dendritic cells. CD80 binds to CD28 and CD152 (CTLA-4). Along with CD86, CD80 plays a critical role in regulation of T cell activation.
CD80 is involved in the costimulatory signal essential for T-lymphocyte activation. T-cell proliferation and cytokine production is induced by the binding of CD28, binding to CTLA-4 has opposite effects and inhibits T-cell activation. The interaction of CD80 with CD28 provides a potent costimulatory signal for T cell activation through the CD3 complex, while its interaction with CTLA-4 provides an inhibitory signal for T cell activation.
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B7-1, B7, BB1, T-lymphocyte activation antigen CD80, CTLA-4 counter-receptor B7.1, Activation B7-1 antigen
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941
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60 kD
