FITC - anti human CD86 - Clone BU63
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產(chǎn)品名稱: FITC - anti human CD86 - Clone BU63
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FITC - anti human CD86 - Clone BU63
FITC - anti human CD86 - Clone BU63
的詳細(xì)介紹
FITC
- anti Human
CD86 - BU63
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BU63
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IgG1
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FCM
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FITC
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Please refer to the Certificate of Analysis for the lot-specific concentration.
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B-lymphoblastoid cell line ARH 77
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Human
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The reagent is provided in aqueous buffered solution containing protein stabilizer, and ≤0.09% sodium azide (NaN3)
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RUO
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CD86, clone B7-2, is a mAb intended for identification of monocytes and dendritic cells and on activated T, NK, and B cells. This reagent is effective for direct IF staining of human tissue for FCM analysis using ≤1 μg/106 cells.
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This antibody reacts with the CD86 antigen, which is expressed at low level on B cells, macrophages, and dendritic cells and is upregulated on B cells through a variety of surface stimuli including the BCR complex, CD40 and some cytokine receptors.
CD86 is also expressed by activated mouse T cells and thioglycolate-elicited peritoneal cells. In addition to CD80 (B7-1), CD86 is a counter-receptor for the T cell surface molecules CD28 and CD152 (CTLA-4). This interaction plays a critical role in T-B crosstalk, T cell costimulation, autoantibody production and Th2-mediated Ig production. The kinetics of upregulation of CD86 upon stimulation, supports its major contribution during the primary phase of an immune response.
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B7-2, B70, Ly-58, Activation B7-2 antigen, B70, BU63, CTLA-4 counter-receptor B7.2, FUN-1,
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942
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80 kDa
