CF-Blue? - anti mouse CD279 - Clone J43.1
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產(chǎn)品名稱: CF-Blue? - anti mouse CD279 - Clone J43.1
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CF-Blue? - anti mouse CD279 - Clone J43.1
CF-Blue? - anti mouse CD279 - Clone J43.1
的詳細(xì)介紹
CF-Blue
- anti Mouse
CD279 - J43.1
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The minimum purchase order quantity for the product is 1
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J43.1
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Armenian Hamster IgG2
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Flow Cytometry
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CF-Blue
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0.5 mg/ml
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Syrian Hamster kidney cell line BKH transfected with Pdcd1 cDNA
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Mouse
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The reagent is provided in aqueous buffered solution containing protein stabilizer, and ≤0.09% sodium azide (NaN3)
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RUO
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CD279, clone J43.1, is a mAb intended for RUO in the identification/enumeration of lymph that express CD279. This reagent is effective for direct IF staining of mouse sample for FCM analysis using ≤1 μg/106 cells.
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Liquid
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Store in the dark at 2-8 °C
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CD297 (PD-1) is a 50-55-kDa glycoprotein encoded by the Pdcd1 gene of the CD28 family of the Ig superfamily. The expression of Pdcd1 mRNA and PD-1 protein is tightly regulated. PD-1 is transiently expressed on CD4-CD8thymocytes, it is upregulated on some cell lines upon induction of apoptosis, it is induced on thymocytes and splenic T and B lymph ocytes after stimulation through their antigen receptors, and it is induced on activated myeloid cells. In addition, Pdcd1 mRNA is transiently expressed in developing B lymph ocytes at the pro-B-cell stage. The presence of an ITIM (Immunoreceptor Tyrosine-based Inhibitory Motif) on PD-1's intracytoplasmic region and the development of splenomegaly and breakdown of peripheral tolerance in PD-1[-/-] mice suggest that PD-1 may be involved in the negative regulation of immune responses. The PD-1 ligands, B7-H1 (also known as PD-L1) and B7-DC (PD-L2), are members of the B7 family of the Ig superfamily. The J43 antibody blocks the binding of PD-1 to its two ligands.
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18566
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50-55 kD
